Improving Cancer Outcomes for African-Americans

改善非裔美国人的癌症治疗结果

• 批准号: 6805223
• 负责人: PATRICK David MAGUIRE
• 金额: $ 63.01万
• 依托单位: NEW HANOVER REGIONAL MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-29 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6805223
• 关键词: African American; behavioral /social science research tag; belief; breast neoplasms; bronchus neoplasm; caucasian American; cervix neoplasms; clinical research; clinical trial phase II; colon neoplasms; combination cancer therapy; cooperative study; data collection methodology /evaluation; head /neck neoplasm; health behavior; health care service utilization; health disparity; health services research tag; human morbidity; human mortality; human subject; larynx neoplasms; medical outreach /case finding; medically underserved population; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; nonsmall cell lung cancer; oral pharyngeal neoplasm; outcomes research; prostate neoplasms; psychological values; quality of life; racial /ethnic difference; rectum neoplasms; religion; uterus neoplasms

DESCRIPTION (provided by applicant) Southeastern North Carolina is a rural area with concentrations of poverty and a large proportion of African-American residents. Within the nine-county service area of the New Hanover Health network are almost 170,000 African-American residents. African-Americans in North Carolina have higher mortality rates, compared with whites, for cancers of the uterine cervix, lung and bronchus, prostate, larynx, oral cavity and pharynx, breast, colon and rectum, and soft tissue. Participation by African-American cancer patients in federally sponsored radiation oncology group clinical trials has the potential to articulate more clearly the factors that contribute to these disparities. Our goal is to increase accrual of African-American cancer patients to radiation therapy group clinical trials through the following: 1) Developing a collaborative partnership with an experienced academic institution that can provide continuing education, consultation, and training in the areas of radiation oncology treatment and research; 2) Identifying and addressing the local factors that inhibit participation in radiation clinical trials; and 3) Developing mechanisms to communicate with patients and providers in surrounding, rural areas to provide consultation and facilitate appropriate referrals for radiation trials. We have developed three pilot studies (the response to the local factors aim, above) to address the following research questions: 1) How does the administration of amifostine during 3D conformal and intensity modulated radiation therapy for head and neck cancer interact with health habits and environmental factors in treatment completion, quality of life, and patient satisfaction with treatment; 2) How does multimodality therapy, including high-dose thoracic RT, chemotherapy, and ZD1839 as a potential radiosensitizer, for locally advanced non-small cell lung cancer yield tolerance and quality of life outcomes that differ by race; 3) How do cognitive and psychosocial factors, namely, relationships with health care providers, religious beliefs, and predicted quality of life, influence the decision of prostate and breast cancer patients to seek, begin, and complete radiation treatment? This project will permit us to contribute to the advancement of medical knowledge and medical practice that will eventually lead to the reduction or elimination of racial disparities in cancer outcomes.

描述（由申请人提供） 北卡罗来纳州东南部是一个农村地区，贫困和非裔美国人居民很大一部分。在新的汉诺威健康网络的9个县服务领域内，有近170,000名非裔美国人居民。与白人相比，北卡罗来纳州的非裔美国人的死亡率更高，对于子宫颈，肺和支气管的癌症，前列腺，前列腺，喉，口腔，口腔和咽，乳腺，结肠和直肠和软组织。非裔美国人癌症患者参与联邦赞助的放射肿瘤学组临床试验有可能更清楚地阐明导致这些差异的因素。 我们的目标是通过以下以下目的将非裔美国癌症患者的应计为放射治疗组临床试验：1）与经验丰富的学术机构建立合作伙伴关系，该机构可以在放射肿瘤学治疗和研究领域提供继续教育，咨询和培训； 2）识别和解决抑制参与辐射临床试验的局部因素； 3）开发与周围农村地区的患者和提供者进行沟通的机制，以提供咨询并促进适当的辐射试验转诊。 我们已经开发了三项试验研究（上面对局部因素的反应）来解决以下研究问题：1）在3D的保形和强度调节的头颈癌期间，amifostine如何在治疗，生活质量，生活质量以及患者满意度治疗的情况下与健康习惯和环境因素相互作用； 2）对于本地高级的非小型非小细胞肺癌的耐受性和随着种族不同的生活质量，包括高剂量胸腔RT，化学疗法和ZD1839在内的多模疗疗法如何作为潜在的放射性敏感剂； 3）认知和社会心理因素，即与医疗保健提供者，宗教信仰以及预测生活质量的关系如何影响前列腺和乳腺癌患者寻求，开始和完成放射治疗的决定？ 该项目将使我们能够为医学知识和医学实践的发展做出贡献，这最终将导致减少或消除癌症结局的种族差异。