Functional Neuroanatomy of Maternal & Paternal Behavior

母体功能神经解剖学

基本信息

批准号：
6902262
负责人：
JEFFREY P LORBERBAUM
金额：
$ 7.3万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-06-01 至 2005-09-25
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6902262
关键词：
auditory stimulus behavioral /social science research tag brain electrical activity brain mapping clinical research cryings functional magnetic resonance imaging gender difference human pregnant subject human subject interview maternal behavior neuroanatomy neuropsychology parent offspring interaction paternal behavior young adult human (21-34)

项目摘要

DESCRIPTION (provided by applicant): The brain basis of human parenting behavior is poorly understood and a functional brain imaging assay such as measuring brain activity with listening to infant cries (caretaking elicitors) might be very helpful in understanding its brain basis. Thus far, we have analyzed results of 3 functional MRI (fMRI) studies in 4, 10, and 40 mothers listening to infant cries, the first two with standard cries minus non-cry control sounds (Lorberbaum et al 1999,2002), and the third with own minus standard infant cries (3 year Child Neglect RFA grant R-01 NS040259 entitled "An fMRI Study Of Healthy Mothers Hearing Infant Cries" now in its no cost extension year and which we label Mother-Cry). This work suggests that brain regions important in rodent maternal behavior also activate when human mothers hear infant cries. This includes the medial preoptic area / ventral bed nucleus of the stria terminalis (MPOA/VBNST) region and its connections to the amygdala, hypothalamus, septal region, midbrain, and the midbrain's projections to the dopaminergic approach pathways that include the striatum, thalamocingulate / medial prefrontal cortex, and lateral paralimbic belt structures (orbitofrontal cortex-insula-temporal pole). We call these regions the "maternal brain circuitry." In this R-03 grant we call Father-Cry, we aim to determine fMRI brain activity differences in fathers and mothers hearing their own infant's cries minus standard infant's cries. As rodent paternal behavior appears to involve similar brain regions to that of maternal behavior, we expect fathers will show increased maternal brain circuit activity, but mothers will show even greater maternal brain circuit activity. Fathers are 14 age-matched husbands of 14 breastfeeding mothers from Mother-Cry. All subjects have completed the study. Fathers' fMRI scans were donated as a university grant-in-kind. We request R-03 funds to perform the Father-Cry data analysis. Parents were recruited at pregnancy week 32 where they were judged psychiatrically and physically healthy and filled out parental-fetal attachment scales. At 5-8 weeks postpartum, parents filled but temperament ratings and ratings of their relationship with their mate and child. They also had their fMRI brain activity measured in response to their own and infant cries, and other controls sounds. Fathers are the perpetrators in 38% of child maltreatment cases. One cannot assume that the neurocircuits of maternal and paternal behavior are the same. Understanding their similarities and differences will help us further lay the groundwork for studying the brain basis of neglectful and abusive parenting and illnesses in which social bonding may be impaired including autism, postpartum depression, anxiety disorders, and substance abuse.

描述（由申请人提供）：人类养育行为的大脑基础知之甚少，功能性大脑成像分析，例如通过听婴儿哭声（照顾诱导子）来测量大脑活动，可能非常有助于理解其大脑基础。到目前为止，我们已经分析了 4、10 和 40 名母亲聆听婴儿哭声的 3 项功能性 MRI (fMRI) 研究结果，前两项使用标准哭声减去非哭声控制声音 (Lorberbaum et al 1999,2002)，并且第三个有自己的负标准婴儿哭声（3 年儿童忽视 RFA 拨款 R-01 NS040259，题为“健康母亲听力的功能磁共振成像研究”） “婴儿哭声”现在处于免费延长年，我们将其标记为“母亲哭声”）。这项工作表明，当人类母亲听到婴儿的哭声时，对啮齿类母性行为重要的大脑区域也会激活。这包括内侧视前区/终纹腹侧床核 (MPOA/VBNST) 区域及其与杏仁核、下丘脑、间隔区、中脑的连接，以及中脑对多巴胺能通路的投射，包括纹状体、丘脑扣带回/内侧前额皮质和外侧旁边缘带结构（眶额皮质-岛叶-颞叶）极）。我们将这些区域称为“母脑回路”。在这项被我们称为“Father-Cry”的 R-03 资助中，我们的目标是确定父亲和母亲在听到自己婴儿的哭声减去标准婴儿哭声时的功能磁共振成像大脑活动差异。由于啮齿类动物的父亲行为似乎涉及与母亲行为相似的大脑区域，我们预计父亲会表现出增加的母亲大脑回路活动，但母亲会表现出更大的母亲大脑回路活动。父亲是《Mother-Cry》中 14 名母乳喂养母亲的 14 名年龄匹配的丈夫。所有受试者均已完成研究。父亲们的功能磁共振成像扫描结果被作为大学实物资助捐赠。我们请求 R-03 资金来执行 Father-Cry 数据分析。在妊娠第 32 周招募父母，评估他们的精神和身体健康状况，并填写父母-胎儿依恋量表。产后 5-8 周，父母填写了气质评分以及与伴侣和孩子的关系评分。他们还测量了功能磁共振成像大脑对自己和婴儿哭声以及其他对照声音的反应的活动。 38% 的虐待儿童案件的肇事者是父亲。人们不能假设母亲和父亲行为的神经回路是相同的。了解它们的异同将有助于我们进一步为研究忽视和虐待的养育方式以及社会联系可能受损的疾病（包括自闭症、产后抑郁症、焦虑症和药物滥用）的大脑基础奠定基础。