Functional Neuroanatomy of Maternal & Paternal Behavior

母体功能神经解剖学

基本信息

批准号：
7069022
负责人：
JEFFREY P LORBERBAUM
金额：
$ 3.66万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7069022
关键词：
auditory stimulus behavioral /social science research tag brain electrical activity brain mapping clinical research cryings functional magnetic resonance imaging gender difference human pregnant subject human subject interview maternal behavior neuroanatomy neuropsychology parent offspring interaction paternal behavior young adult human (21-34)

项目摘要

DESCRIPTION (provided by applicant): The brain basis of human parenting behavior is poorly understood and a functional brain imaging assay such as measuring brain activity with listening to infant cries (caretaking elicitors) might be very helpful in understanding its brain basis. Thus far, we have analyzed results of 3 functional MRI (fMRI) studies in 4, 10, and 40 mothers listening to infant cries, the first two with standard cries minus non-cry control sounds (Lorberbaum et al 1999,2002), and the third with own minus standard infant cries (3 year Child Neglect RFA grant R-01 NS040259 entitled "An fMRI Study Of Healthy Mothers Hearing Infant Cries" now in its no cost extension year and which we label Mother-Cry). This work suggests that brain regions important in rodent maternal behavior also activate when human mothers hear infant cries. This includes the medial preoptic area / ventral bed nucleus of the stria terminalis (MPOA/VBNST) region and its connections to the amygdala, hypothalamus, septal region, midbrain, and the midbrain's projections to the dopaminergic approach pathways that include the striatum, thalamocingulate / medial prefrontal cortex, and lateral paralimbic belt structures (orbitofrontal cortex-insula-temporal pole). We call these regions the "maternal brain circuitry." In this R-03 grant we call Father-Cry, we aim to determine fMRI brain activity differences in fathers and mothers hearing their own infant's cries minus standard infant's cries. As rodent paternal behavior appears to involve similar brain regions to that of maternal behavior, we expect fathers will show increased maternal brain circuit activity, but mothers will show even greater maternal brain circuit activity. Fathers are 14 age-matched husbands of 14 breastfeeding mothers from Mother-Cry. All subjects have completed the study. Fathers' fMRI scans were donated as a university grant-in-kind. We request R-03 funds to perform the Father-Cry data analysis. Parents were recruited at pregnancy week 32 where they were judged psychiatrically and physically healthy and filled out parental-fetal attachment scales. At 5-8 weeks postpartum, parents filled but temperament ratings and ratings of their relationship with their mate and child. They also had their fMRI brain activity measured in response to their own and infant cries, and other controls sounds. Fathers are the perpetrators in 38% of child maltreatment cases. One cannot assume that the neurocircuits of maternal and paternal behavior are the same. Understanding their similarities and differences will help us further lay the groundwork for studying the brain basis of neglectful and abusive parenting and illnesses in which social bonding may be impaired including autism, postpartum depression, anxiety disorders, and substance abuse.

描述（由申请人提供）：人类育儿行为的大脑基础知之甚少，功能性的脑成像测定法，例如通过听婴儿哭泣（CareTaking Inticertors）测量大脑活动（脑活动）可能对理解其大脑的基础非常有帮助。到目前为止，我们已经分析了4、10和40位听婴儿哭泣的母亲进行3项功能性MRI（fMRI）研究的结果，前两个具有标准的哭泣声显得无关控制的声音（Lorbabaum等，1999,2002），以及第三次，具有自己的SINUS STANDARD婴儿哭泣（3年的儿童疏忽了RFA RFA RFA R-01 NSS01 NS01 NS01 NS01259 NOTHETHENT”婴儿哭泣：“现在，我们的成本延长一年，我们为母亲标记）。这项工作表明，当人母亲听到婴儿哭泣时，对啮齿动物孕产妇行为重要的大脑区域也会激活。这包括Stria末端（MPOA / VBNST）区域的上内侧区域 /腹侧床核及其与杏仁核，下丘脑，中间区域，中脑，中脑，中脑以及中脑对多巴胺能途径的预测，其中包括纹状体，丘脑前派的培养基和培养基范围，并培养甲状腺素的途径，以及（Orbitrontal Cortex-Insula-tormoral-pole）。我们将这些区域称为“母脑电路”。在我们称为父亲的R-03赠款中，我们的目标是确定父亲的fMRI大脑活动差异，而母亲听到自己的婴儿的哭声则减去了标准婴儿的哭泣。由于啮齿动物的父亲行为似乎涉及与孕产妇行为相似的大脑区域，因此我们预计父亲会显示出孕妇脑电路活动的增加，但母亲会显示出更大的母体脑电路活动。父亲是来自母亲的14个母乳喂养母亲的14个年龄匹配的丈夫。所有受试者都完成了这项研究。父亲的功能磁共振成像扫描被捐赠为大学赠款。我们要求R-03资金执行父亲数据分析。父母在第32周招募了父母，他们在精神上和身体健康并填写了父母的依恋量表。产后5-8周，父母填补了与伴侣和孩子的关系的气质评级和评级。他们还根据自己的和婴儿的哭声和其他控制声音测量了fMRI大脑活动。父亲是38％的虐待案件中的肇事者。人们不能假设母亲和父亲行为的神经通路是相同的。了解他们的相似性和差异将有助于我们进一步为研究忽视和虐待的育儿和疾病的大脑基础奠定基础，在这些大脑基础上，社会联系可能会受到损害，包括自闭症，产后抑郁症，焦虑症和药物滥用。