Proposal for a Chicago-CRIC Clinical Center

芝加哥-CRIC 临床中心提案

• 批准号: 7016194
• 负责人: JAMES P. LASH
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7016194
• 关键词: blood chemistry; cardiovascular disorder; cardiovascular imaging /visualization; chronic renal failure; clinical research; cooperative study; disease /disorder proneness /risk; epidemiology; glomerular filtration rate; human morbidity; human mortality; human subject; longitudinal human study; noninvasive diagnosis; urinalysis

DESCRIPTION(provided by applicant): Individuals with chronic renal insufficiency (CRI) represent a large and growing segment of our population, with much of the recent growth fueled by the increased incidence of diabetes. The adverse impact of cardiovascular disease (CVD) in the end stage renal disease (ESRD) population has its beginnings earlier, during the course of CRI, but associated risk factors have not been completely characterized. The overlap between several CVD and renal disease risk factors suggests interactions between CRI and CVD that are not completely understood. The primary goals of the Prospective Cohort Study of Chronic Renal Insufficiency (CRIC) are to determine the risk factors for accelerated decline in renal function and to determine the incidence of, and identify risk factors for, cardiovascular disease in the CRI population. The proposed Chicago-CRIC Consortium is a group of closely tied institutions with a history of previous collaborations, serving a geographically compact and densely populated area, serving an adult patient population of several million among which an estimated 96,000 have CRI with GFRs in the range of 30-70 ml/min/1.73m2. Using our previously effective strategies in recruiting for the NIH-sponsored African American Study of Kidney Disease and Hypertension (AASK) and HEMO trials, we will recruit and retain 500 men and women with chronic renal insufficiency (CRI) from patients served by Chicago-CRIC institutions. The Chicago-CRIC Clinical Center will provide yearly Comprehensive Visits for six to seven years, which will include 125-iothalamate GFRs, blood pressure measurements, anthropometrics, urine and blood testing, and cardiovascular imaging (electron beam tomograpy [EBT], echocardiography, and carotid ultrasound). In addition, we will provide regular morbidity and mortality follow-up, which will include the tracking and classification of renal and cardiovascular endpoints. The strengths of the Chicago-CRIC Clinical Center are the established history of collaboration between the member institutions, our experience as investigators in two previous large NIH multicenter clinical studies involving renal patients (AASK and HEMO), the utilization of an existing, N1H-funded General Clinical Research Center (GCRC) for all study visits, and our ability to access databases containing a very large CRI population.

描述（由申请人提供）： 患有慢性肾功能不全（CRI）的人代表一个大的人 我们人口的不断增长，最近的大部分增长助长了 糖尿病发生率增加。心血管疾病的不利影响 （CVD）在末期肾脏疾病（ESRD）的开始 早些时候，在CRI过程中，但相关的风险因素尚未 完全表征。几种CVD和肾脏疾病之间的重叠 风险因素表明CRI和CVD之间的相互作用并非完全 理解。前瞻性队列研究的慢性肾脏研究的主要目标 功能不全（CRIC）是确定加速下降的危险因素 在肾功能并确定的发生率并确定风险因素的发生率 对于CRI人群中的心血管疾病。拟建的芝加哥危机 财团是一群与以前的历史的紧密联系的机构 合作，服务于地理上紧凑且人口稠密的地区， 为成年患者人口提供数百万的患者人群，其中估计 96,000的CRI的GFR在30-70 mL/min/1.73m2的范围内。使用我们的 以前有效的NIH赞助的非洲人招募的策略 美国对肾脏疾病和高血压（AASK）和血液试验的研究，我们 将招募和保留500名慢性肾功能不全的男女 （CRI）来自芝加哥 - 危机机构服务的患者。芝加哥 - 危机 临床中心将提供六到七的年度全面访问 年，其中包括125个iothalamate GFR，血压测量， 人类学，尿液和血液测试以及心血管成像（电子 梁tomograpy [EBT]，超声心动图和颈动脉超声检查）。此外， 我们将提供定期的发病率和死亡率随访，其中包括 肾脏和心血管终点的跟踪和分类。这 芝加哥 - 危机临床中心的优势是既定历史 成员机构之间的合作，我们作为调查人员的经验 在之前的两个大型NIH多中心临床研究中，涉及肾脏患者 （AASK和HEMO），现有N1H资助的一般临床的利用 研究中心（GCRC）进行所有研究访问，我们的访问能力 包含非常大的CRI人群的数据库。