Does Tel2p act DNA double-strand breaks?

Tel2p 是否具有 DNA 双链断裂作用？

• 批准号: 6949086
• 负责人: RONALD E HECTOR
• 金额: $ 3.28万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6949086
• 关键词: Caenorhabditis elegans; DNA; DNA damage; DNA repair; binding proteins; cell biology; cell death; chromatin immunoprecipitation; fungal genetics; fungal proteins; gene mutation; molecular genetics; phosphorylation; polymerase chain reaction; postdoctoral investigator; protein binding; telomere

DESCRIPTION (provided by applicant): The overall goal of this project is to apply bioinformatic and genetic approaches to study the control of life span using Saccharomyces cerevisiae as a model system. Specifically, this study will use transcriptional profiling of multiple long-lived and short-lived mutants to identify genes required for mitotic and post-mitotic aging. The genes identified will be grouped into genetic pathways based on phenotypes associated with altered life span as well as their requirement for normal life span. Regulatory components of the life span controlling pathways will be identified using bioinformatics tools to determine statistically significant over-represented groups of functionally related genes and sequence elements that may regulate their transcription. The results from these studies will provide a valuable model system for understanding the mechanism of life span control in all model organisms.

描述（由申请人提供）：该项目的总体目标是应用生物信息学和遗传学方法，以酿酒酵母作为模型系统来研究寿命的控制。具体来说，这项研究将使用多个长寿命和短寿命突变体的转录分析来识别有丝分裂和有丝分裂后衰老所需的基因。所识别的基因将根据与寿命改变相关的表型及其对正常寿命的要求分为遗传途径。将使用生物信息学工具来识别寿命控制途径的调节成分，以确定统计学上显着的过度代表性的功能相关基因和可能调节其转录的序列元件组。这些研究的结果将为理解所有模型生物的寿命控制机制提供一个有价值的模型系统。