Diet, Hormone Replacement Therapy and Breast Cancer

饮食、激素替代疗法和乳腺癌

• 批准号: 6943524
• 负责人: SHUMIN ZHANG
• 金额: $ 13.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-12 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943524
• 关键词: alcoholic beverage consumption; aspirin; breast neoplasms; caffeine; cancer prevention; clinical research; clinical trials; dietary fiber; estrogens; female; folate; hormone therapy; human subject; human therapy evaluation; longitudinal human study; nutrition aspect of cancer; nutrition related tag; patient oriented research; progestins; questionnaires; radioimmunoassay; tocopherols; women' s health

DESCRIPTION (provided by applicant): This is a resubmission of I K07 CA096619-01 "Diet, Hormone Replacement Therapy and Breast Cancer". Candidate: Shumin Zhang received her MD at the Harbin Medical University in 1986 and her ScD in epidemiology and nutrition at the Harvard School of Public Health in 1998. She then completed her post-doctoral training in 2000, and now is an Assistant Professor of Medicine at the Harvard Medical School (HMS). She applies for this Career Development Award to acquire the methodological and theoretical research skills needed to become an independent scientist in cancer and nutritional epidemiology. Sponsor and Environment: JoAnn Manson, MD, DrPH, is the Chief of the Division of Preventive Medicine at the Brigham and Women's Hospital, Professor of Medicine at the HMS and Co Principal investigator (Co-Principal Investigator) of the Women's Health Study ONHS). Julie Buring, ScD, is the Deputy Director of the Division, Professor of Ambulatory Care and Prevention at the HMS and Principal Investigator of the WHS. They have trained numerous investigators in the fields of diet, lifestyle and chronic diseases, areas in which they have published extensively. Research: We plan to conduct a prospective analysis within the WHS, an ongoing clinical trial of vitamin E and low-dose aspirin in the primary prevention of cancer and cardiovascular disease among 39,876 women. We will test 4 dietary hypotheses that moderate alcohol intake increases risk of breast cancer, whereas high intake of folate and fiber reduces risk; and caffeine intake is not associated with risk. We will link fiber intake to plasma endogenous sex steroid hormones in a subsample of the WHS. We will also test 4 hormone replacement therapy (HRT) hypotheses that tong-term use of estrogen plus progestin increases risk of breast cancer more than estrogen alone; estrogen plus cyclic progestin increases risk more than estrogen plus continuous progestin; low-dose estrogens confer lower risk than high-dose; and use of estrogen is more strongly associated with risk among women drinking alcohol. The ongoing WHS will provide updated and repeated measures of HRT, comprehensive dietary assessment at baseline, and important covariates for breast cancer in addition to follow-up of the cohort and documentation of breast cancer cases (expected N = 1550). The findings from this project could have direct clinical application for efforts to reduce risk of breast cancer.

描述（由申请人提供）：这是I K07 CA096619-01“饮食，激素替代疗法和乳腺癌”的重新提交。 候选人：Shumin Zhang于1986年在Harbin医科大学获得了医学博士学位，并于1998年在哈佛公共卫生学院获得了流行病学和营养的SCD。然后，她于2000年完成了博士后培训，现在是哈佛医学院（HMS）的医学助理教授。 她申请了这一职业发展奖，以获得成为癌症和营养流行病学独立科学家所需的方法论和理论研究技能。 赞助商和环境：医学博士Joann Manson是Brigham and妇女医院的预防医学司司，HMS医学教授和CO首席研究员（共同研究人员）妇女健康研究ONHS）。 SCD朱莉·布林（Julie Buring）是HMS的HMS和WHS首席调查员的副主任，卧床护理和预防教授。 他们已经培训了众多饮食，生活方式和慢性疾病领域的调查人员，这些研究人员已广泛发表。 研究：我们计划在WHS中进行前瞻性分析，这是一项正在进行的维生素E和低剂量阿司匹林的临床试验，以预防39,876名妇女的癌症和心血管疾病。 我们将测试4个饮食假设，这些假设适度增加酒精的摄入量增加了乳腺癌的风险，而叶酸和纤维的高摄入量则降低了风险；咖啡因的摄入量与风险无关。 我们将在WHS子样本中将纤维摄入与血浆内源性类固醇激素联系起来。 我们还将测试4种激素替代疗法（HRT）假设雌激素加孕激素的使用比单独使用雌激素更多地增加了乳腺癌的风险。雌激素加环节孕激素比雌激素加上连续孕激素增加风险。低剂量雌激素的风险低于高剂量；雌激素的使用与饮酒妇女的风险更加密切相关。 正在进行的WHS还将提供HRT的更新和重复测量，基线时进行全面的饮食评估以及对乳腺癌的重要协变量，除了对乳腺癌病例的随访和记录（预计n = 1550）。 该项目的发现可能会直接临床应用，以减少乳腺癌的风险。