Diet, Hormone Replacement Therapy and Breast Cancer

饮食、激素替代疗法和乳腺癌

• 批准号: 7114382
• 负责人: SHUMIN ZHANG
• 金额: $ 13.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-12 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114382
• 关键词: alcoholic beverage consumption; aspirin; breast neoplasms; caffeine; cancer prevention; clinical research; clinical trials; dietary fiber; estrogens; female; folate; hormone therapy; human subject; human therapy evaluation; longitudinal human study; nutrition aspect of cancer; nutrition related tag; patient oriented research; progestins; questionnaires; radioimmunoassay; tocopherols; women' s health

DESCRIPTION (provided by applicant): This is a resubmission of I K07 CA096619-01 "Diet, Hormone Replacement Therapy and Breast Cancer". Candidate: Shumin Zhang received her MD at the Harbin Medical University in 1986 and her ScD in epidemiology and nutrition at the Harvard School of Public Health in 1998. She then completed her post-doctoral training in 2000, and now is an Assistant Professor of Medicine at the Harvard Medical School (HMS). She applies for this Career Development Award to acquire the methodological and theoretical research skills needed to become an independent scientist in cancer and nutritional epidemiology. Sponsor and Environment: JoAnn Manson, MD, DrPH, is the Chief of the Division of Preventive Medicine at the Brigham and Women's Hospital, Professor of Medicine at the HMS and Co Principal investigator (Co-Principal Investigator) of the Women's Health Study ONHS). Julie Buring, ScD, is the Deputy Director of the Division, Professor of Ambulatory Care and Prevention at the HMS and Principal Investigator of the WHS. They have trained numerous investigators in the fields of diet, lifestyle and chronic diseases, areas in which they have published extensively. Research: We plan to conduct a prospective analysis within the WHS, an ongoing clinical trial of vitamin E and low-dose aspirin in the primary prevention of cancer and cardiovascular disease among 39,876 women. We will test 4 dietary hypotheses that moderate alcohol intake increases risk of breast cancer, whereas high intake of folate and fiber reduces risk; and caffeine intake is not associated with risk. We will link fiber intake to plasma endogenous sex steroid hormones in a subsample of the WHS. We will also test 4 hormone replacement therapy (HRT) hypotheses that tong-term use of estrogen plus progestin increases risk of breast cancer more than estrogen alone; estrogen plus cyclic progestin increases risk more than estrogen plus continuous progestin; low-dose estrogens confer lower risk than high-dose; and use of estrogen is more strongly associated with risk among women drinking alcohol. The ongoing WHS will provide updated and repeated measures of HRT, comprehensive dietary assessment at baseline, and important covariates for breast cancer in addition to follow-up of the cohort and documentation of breast cancer cases (expected N = 1550). The findings from this project could have direct clinical application for efforts to reduce risk of breast cancer.

描述（由申请人提供）：这是 I K07 CA096619-01“饮食、激素替代疗法和乳腺癌”的重新提交。 候选人：张淑敏1986年在哈尔滨医科大学获得医学博士学位，1998年在哈佛大学公共卫生学院获得流行病学和营养学博士学位。2000年完成博士后培训，现任医学助理教授在哈佛医学院（HMS）。 她申请该职业发展奖，以获得成为癌症和营养流行病学独立科学家所需的方法和理论研究技能。 赞助商和环境：JoAnn Manson，医学博士，DrPH，布莱根妇女医院预防医学科主任，HMS 医学教授，以及妇女健康研究 ONHS 的联合首席研究员（Co-Principal Investigator） 。 Julie Buring，ScD，是该部门的副主任、HMS 的门诊护理和预防教授以及 WHS 的首席研究员。 他们在饮食、生活方式和慢性病领域培训了众多研究人员，并在这些领域发表了大量文章。 研究：我们计划在 WHS 中进行前瞻性分析，这是一项正在进行的临床试验，涉及 39,876 名女性，使用维生素 E 和低剂量阿司匹林来一级预防癌症和心血管疾病。 我们将测试 4 个饮食假设：适量饮酒会增加患乳腺癌的风险，而大量摄入叶酸和纤维会降低风险；咖啡因摄入量与风险无关。 我们将在 WHS 子样本中将纤维摄入量与血浆内源性类固醇激素联系起来。 我们还将测试 4 个激素替代疗法 (HRT) 假设，即长期使用雌激素加孕激素比单独使用雌激素更能增加患乳腺癌的风险；雌激素加周期性孕激素比雌激素加连续孕激素增加的风险更大；低剂量雌激素比高剂量雌激素风险更低；雌激素的使用与女性饮酒的风险更为密切相关。 正在进行的 WHS 除了队列的随访和乳腺癌病例的记录（预期 N = 1550）之外，还将提供 HRT 的更新和重复测量、基线全面饮食评估以及乳腺癌的重要协变量。 该项目的研究结果可直接应用于降低乳腺癌风险的临床应用。