UTMB MASS SPECTROMETRY/PROTEOMICS FACILITY

UTMB 质谱/蛋白质组学设施

• 批准号: 6861022
• 负责人: ALEXANDER none KUROSKY
• 金额: $ 26.43万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-13 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6861022
• 关键词: aldehydes; biomedical facility; chemical carcinogen; chemical carcinogenesis; complementary DNA; deoxyguanosine; gel electrophoresis; glutathione transferase; isozymes; mass spectrometry; proteomics; recombinant proteins

DESCRIPTION: (Applicant's Description) This proposal is aimed at developing a mass spectrometry/proteomics facility to provide UTMB investigators with enhanced analytical capabilities to identify and characterize proteins associated with cancer and oncological changes in protein expression. There are approximately 37 NCI-supported grants at UTMB with a combined total current direct cost funding of about $13.2 million dollars. Seven of these NCI-supported projects are described to underscore the critical importance of developing a mass spectrometry and proteomics core facility at UTMB. This facility will operate within the UTMB Protein Chemistry Laboratory, an established centralized core service that has a strong history of providing the UTMB research community with analytical services relating to proteins, peptides, and amino acids. This grant will allow UTMB cancer researchers to take advantage of new developments and capabilities in the area of protein/peptide characterization by mass spectrometry, and so considerably enhance NCI-supported research on the campus. Grant funds will be initially used to purchase proteomics equipment, and on an ongoing basis, to provide the necessary personnel, supplies, and partial service contracts to operate the facility. Support is also requested to stimulate new and young investigator cancer research by providing cutting-edge technology for the identification of disease-associated protein expression. In addition to the seven described NCI- funded projects, other NIH research investigators at UTMB are also expected to benefit from this grant. In general, funding from this grant will significantly reduce the charge-back fees for analyses, and so encourage cancer investigators to utilize this resource. UTMB's commitment to developing this facility is underscored by a considerable contribution of space, equipment, and salary support. An advisory committee is in place to insure that the goals of the grant are achieved and that the facility will continue to operate into future years.

描述：（申请人的描述）该建议旨在开发一个 质谱/蛋白质组学设施为UTMB调查人员提供 增强的分析能力以识别和表征蛋白质 与癌症和蛋白质表达的肿瘤学变化有关。那里 在UTMB上约有37个NCI支持的赠款，总计合并 当前的直接成本资金约为1320万美元。其中七个 描述了NCI支持的项目是为了强调 在UTMB开发质谱和蛋白质组学核心设施。这 设施将在UTMB蛋白化学实验室内运行，这是一个 建立的集中核心服务，有悠久的历史 UTMB研究社区具有与蛋白质有关的分析服务， 肽和氨基酸。这项赠款将使UTMB癌症研究人员得以 利用该领域的新发展和能力 质谱法表征蛋白质/肽，因此 增强了NCI支持的校园研究。赠款资金最初将是 用于购买蛋白质组学设备，并持续使用 必要的人员，供应和部分服务合同，以操作 设施。还要求支持以刺激新的和年轻的研究者 通过提供尖端技术来识别癌症研究 与疾病相关的蛋白质表达。除了七个描述的nci- 资助的项目，UTMB的其他NIH研究人员也有望 从这笔赠款中受益。通常，这笔赠款的资金将 显着降低分析的抵押费用，因此鼓励 癌症研究人员利用此资源。 UTMB对 开发此设施的贡献很大 空间，设备和工资支持。咨询委员会已成为 确保实现赠款的目标，并将设施 继续进入未来的几年。