ALDH2, ADH1B and Alcohol Expectancies in Asian Americans

亚裔美国人的 ALDH2、ADH1B 和酒精预期

• 批准号: 7156467
• 负责人: Christian S Hendershot
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-16 至 2009-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156467
• 关键词: Asian Americans; Chinese American; alcoholic beverage consumption; alcoholism /alcohol abuse; aldehyde dehydrogenases; behavioral genetics; clinical research; disease /disorder etiology; gender difference; gene environment interaction; genetic polymorphism; genotype; human subject; predoctoral investigator; psychometrics; questionnaires; racial /ethnic difference; social psychology; substance abuse related behavior

DESCRIPTION (provided by applicant): Recent evidence suggests increasing rates of heavy drinking and alcohol use disorders among Asian Americans. Polymorphisms in ALDH2 and ADH1B genotypes are demonstrated to influence alcohol sensitivity and drinking behavior in Asians, however, few studies have attempted to examine genetic factors in context with psychosocial theories of alcohol use. The overarching aim of this research is to identify psychosocial mechanisms by which genetic factors influence drinking in Asian Americans. It is proposed that alcohol expectancy theory offers a tenable conceptual framework through which genetic effects on drinking may be understood, and that expectancies specific to the "flushing response" to alcohol (i.e., physiological expectancies) mediate genetic influences on drinking. In Study 1, qualitative methods will be employed to develop a novel measure of physiological expectancies specific to the flushing response associated with variation in ALHD2 and ADH1B genotypes. Study 2 seeks to validate this measure in a sample of 300 Asian Americans. Study 3 will recruit 180 Chinese- and Korean-American undergraduates from an ongoing study of college student drinking and will employ genotyping procedures to establish ALDH2 and ADH1B status. Relationships between genetic factors and expectancies will be examined, and expectancies will be evaluated as a mediator of genetic effects on drinking. Ethnic and gender differences will also be examined. By jointly examining genetic and psychosocial factors related to drinking, this research aims to further a biopsychosocial account of alcohol use etiology in Asian Americans.

描述（由申请人提供）：最近的证据表明，亚裔美国人的大量饮酒和酒精使用障碍率提高。证明ALDH2和ADH1B基因型中的多态性会影响亚洲人的酒精敏感性和饮酒行为，但是，很少有研究试图以饮酒的心理社会理论来检查遗传因素。这项研究的总体目的是确定遗传因素影响亚裔美国人饮酒的社会心理机制。有人提出，酒精预期理论提供了一个可替代的概念框架，可以理解遗传对饮酒的遗传影响，并且对酒精的“潮红反应”（即生理期望）的预期介导了对饮酒的遗传影响。在研究1中，将采用定性方法来开发一种与ALHD2和ADH1B基因型变化相关的潮红反应特异性的新型生理期望值度量。研究2试图在300名亚裔美国人样本中验证这一措施。研究3将从正在进行的大学生饮酒的研究中招募180名中国和韩裔美国人的本科生，并采用基因分型程序来建立ALDH2和ADH1B状态。将检查遗传因素与期望之间的关系，预期能力将作为遗传对饮酒的介体进行评估。还将检查种族和性别差异。通过共同研究与饮酒有关的遗传和社会心理因素，该研究旨在进一步对亚裔美国人的酒精使用病因进行生物心理社会的描述。