A Role of the IGF-1 Receptor In Aging

IGF-1 受体在衰老中的作用

基本信息

批准号：
6941593
负责人：
RENATO Luigi BASERGA
金额：
$ 31.26万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2007-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6941593
关键词：
binding proteins biological signal transduction cell differentiation cell growth regulation cell senescence growth factor receptors guanine nucleotide binding protein insulinlike growth factor longevity oncoproteins tissue /cell culture transcription factor

项目摘要

DESCRIPTION (provided by applicant): The type 1 insulin-like growth factor receptor (IGF-1R) is known to play an important role in aging. My laboratory has been interested for some time in the biology of the IGF-1R and its signaling. Recently, we have found that the IGF-1R, directly or indirectly, modulates the expression and/or the activity of three proteins, all of which have been implicated in aging, either in vivo or in vitro. These three proteins are: 1) the Id proteins, that are transcriptional factors involved in the control of cell proliferation and cell differentiation. The Idl protein has been shown to delay cellular senescence. 2) the Ras oncoprotein, which, in certain circumstances, induces a senescent-like state in cells in culture. 3) the p66 isoform of the Shc proteins, that plays a role in the longevity of mice. The involvement of the IGF-1R in the regulation of Id gene expression and the stabilization of Ras are findings original in our laboratory and completely novel. The role of p66 in IGF-IR signaling has been studied in other laboratories as well as ours, but very little information has emerged so far. The combination of a receptor and three signaling proteins all involved in aging constitute an area of investigation, that combines basic cell biology and relevance to aging. This project requires a close interaction with at least two other projects in the present application.

描述（由申请人提供）：类型1胰岛素样生长因子已知受体（IGF-1R）在衰老中起重要作用。我的实验室在IGF-1R的生物学及其的生物学中一直感兴趣信号。最近，我们发现IGF-1R直接或间接，调节三种蛋白质的表达和/或活性已经与体内或体外有关的衰老与衰老有关。这三个蛋白质是：1）ID蛋白，是涉及的转录因素细胞增殖和细胞分化的控制。 IDL蛋白已显示出延迟细胞衰老。 2）Ras癌蛋白，该蛋白在某些情况，在培养中诱导细胞中的衰老状态。 3）SHC蛋白的P66同工型，在寿命中起作用老鼠。 IGF-1R参与ID基因表达的调节 RA的稳定是我们实验室中原始的发现，完全新颖。 p66在IGF-IR信号传导中的作用已在其他实验室和我们的实验室，但信息的出现很少，所以远的。一个受体和三个信号蛋白的组合都涉及在衰老中构成了一个研究领域，该领域结合了基本细胞生物学与衰老有关。该项目需要与AT进行密切互动本应用程序中至少有两个项目。