How do infant gut microbes use N-glycans from breast milk as a nutrient source?

婴儿肠道微生物如何利用母乳中的 N-聚糖作为营养源？

• 批准号: 2594480
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2594480
• 关键词: How; do; infant; gut; microbes

The human gut microbiota has a mutualistic relationship with the host, creating a profound but poorly understood impact of host health, development, and disease. Glycans are the main nutrient source for the gut microbiota and these can come from dietary fibre of human glycoproteins, for example. Species of Bifidobacterium are the dominant bacteria found in an infant's gut and are critical to the development of a healthy gut. Breast milk contains numerous bioactive components that have evolved to specifically feed Bifidobacterium species present in an infant's gut. This project will determine how N-glycans on breast milk proteins are used as a nutrients source by these species. A combination of techniques will be used, including: bacterial growth, glycan and sugar analysis, enzyme production, and enzyme characterisation.

人类肠道微生物群与宿主存在着互利共生的关系，对宿主的健康、发育和疾病产生了深远但人们知之甚少的影响。聚糖是肠道微生物群的主要营养来源，例如，它们可以来自人类糖蛋白的膳食纤维。双歧杆菌是婴儿肠道中发现的优势细菌，对健康肠道的发育至关重要。母乳含有许多生物活性成分，这些成分已经进化到专门喂养婴儿肠道中存在的双歧杆菌。该项目将确定这些物种如何利用母乳蛋白质上的 N-聚糖作为营养来源。将使用多种技术的组合，包括：细菌生长、聚糖和糖分析、酶生产和酶表征。