Core--(Primate Studies) Radiation countermeasure center

核心--（灵长类研究）辐射对策中心

• 批准号: 7052931
• 负责人: J. MARK CLINE
• 金额: $ 64.34万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052931
• 关键词: Macaca fascicularis; animal care; biomedical facility; cooperative study; ionizing radiation; radiation dosage; radiation protection; radiation recovery

This project is a Primate Studies Core for a multi-institutional Radiation Countermeasures Consortium.The Core will help conduct studies of drugs that may protect the health of people exposed to radiation, as in the case of a terrorist attack involving a "dirty bomb" or nuclear bomb. Because of the high degree of genetic and functional similarity between nonhuman primates and human beings, this core resource is a critical component of candidate radiation-protective drugs, in an experimental setting under which radiation can be given to healthy subjects (which cannot be done in people). This core will serve programs in Normal Tissue Injury, Bone Marrow Recovery, and Immunity programs. Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates including irradiation; veterinary medical care and management of bone-marrow-suppressed animals; diseases of primates; pathology of radiation injury; blood testing and hormonal regulation in primates; and adaptation of genetic techniques to the primate model. Core services will include acquisition and maintenance of disease-free primates, exposure of animals to radiation, administration of therapeutic interventions to prevent radiation damage, and clinical and pathologic assessments of treatment outcomes in nonhuman primates, including post-mortem examination and tissue collection and sharing for both baseline characterization of radiation responses and assessment of mitigating interventions. The Core will also provide extensive data management services for primate studies including data sharing.

该项目是多机构辐射对策联盟的灵长类动物研究核心。该核心将帮助研究可能保护暴露于辐射的人们的健康的药物，例如涉及“脏弹”的恐怖袭击或核弹。由于非人类灵长类动物和人类之间的遗传和功能高度相似，这一核心资源是候选辐射防护药物的关键组成部分，在实验环境下可以对健康受试者进行辐射（这在人类中是不可能完成的）人们）。该核心将为正常组织损伤、骨髓恢复和免疫项目提供服务。核心研究人员在非人类灵长类动物的实验使用和临床医学（包括辐射）方面拥有独特的技能；兽医医疗 骨髓抑制动物的管理；灵长类动物疾病；放射损伤病理学；灵长类动物的血液检测和激素调节；以及遗传技术对灵长类动物模型的适应。核心服务将包括获得和维持无病灵长类动物、动物暴露于辐射、实施治疗干预措施以防止辐射损伤，以及对非人类灵长类动物治疗结果的临床和病理评估，包括尸检以及组织收集和共享用于辐射反应的基线特征和缓解干预措施的评估。该核心还将为灵长类动物提供广泛的数据管理服务 研究，包括数据共享。