CORE--PRIMATE

核心——灵长类

• 批准号: 6201410
• 负责人: Ronald C Desrosiers
• 金额: $ 11.68万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6201410
• 关键词: Callithricidae; Macaca fascicularis; Macaca mulatta; Primates; Saimiri; animal breeding; animal care; animal tissue; biomedical facility; disease /disorder model; simian AIDSs

The Primate Core at the New England Regional Primate Research Center will be used to test specific hypotheses that arise from basic research or clinical activities of the University of Massachusetts Medical Center CFAR. The Primate Core will translate basic research of clinical observations into specific hypothesis-driven experiments using SIV or SHIV in rhesus monkeys. The New England Regional Primate Research Center maintains approximately 1300 non-human primates and is capable of housing over 100 SIV-or SHIV-infected rhesus monkeys in a specially designed biocontainment facility. The New England Regional Primate Research Center is extensively supported by NIH-funded research programs from the National Center for Research Resources and from the categorical Institutes. The Primate Core will be directed by Dr. Ronald Desrosiers, who has extensive experience in the design and execution of AIDS research projects utilizing non-human primates. The Primate Core will provide partial support for an animal care technician and laboratory technician. A variety of assays will be performed under the Primate Core using samples derived from experimentally-infect animals. The Primates Core will also provides serum, tissue, virus and clone reagents to CFAR investigators. Joint conferences, which already have been taking place, will foster continued interactions, collaborations, and exchanges.

新英格兰地区灵长类研究中心的灵长类核心将 用于检验基础研究中产生的具体假设或 马萨诸塞大学医学中心的临床活动 恒虚警。灵长类核心将转化临床基础研究 使用 SIV 或 SHIV 对特定假设驱动的实验进行观察 在恒河猴中。新英格兰地区灵长类研究中心 饲养着大约 1300 只非人类灵长类动物，并且能够居住 超过 100 只感染 SIV 或 SHIV 的恒河猴在专门设计的环境中 生物防护设施。新英格兰地区灵长类研究中心 得到 NIH 资助的国家研究计划的广泛支持 研究资源中心和分类研究所。这 Primate Core 将由 Ronald Desrosiers 博士指导，他在 设计和执行艾滋病研究项目的经验 非人类灵长类动物。 Primate Core 将为 动物护理技术员和实验室技术员。多种检测将 使用来自灵长类动物核心的样本进行 实验感染动物。灵长类核心还将提供血清， 向 CFAR 研究人员提供组织、病毒和克隆试剂。联合会议， 已经发生的事情将促进持续的互动， 合作、交流。