Software For The Analysis Of Hormone Pulsatility

激素脉动分析软件

• 批准号: 6922083
• 负责人: MICHAEL Linn JOHNSON
• 金额: $ 46.09万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922083
• 关键词: Internet; automated data processing; computer graphics /printing; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; educational resource design /development; hormone metabolism; interactive multimedia; method development; statistics /biometry; workshop

DESCRIPTION (provided by applicant): This proposal will create an integrated software package for investigation of hormone concentration-time series by further development, extension, validation, and distribution of the data analysis algorithms and software created by our group over the last twenty years. These programs explore the aperiodic fluctuations that are typical for serum concentration profiles of many neuroendocrine and peripherally secreted hormones. Extensive experimental and theoretical work documents the physiological importance of these fluctuations that could be altered by pathophysiology, or could mediate key intra- and interspecies distinctions. However, the evolving demands of endocrine researchers cannot be adequately addressed by our current programs, which are based on outdated computer platforms, user interfaces, and lack extensive documentation. Accordingly, we propose to develop an integrated package of advanced data analysis algorithms, attendant software and documentation for multifaceted investigation of endocrine concentration-time series. The suite will encompass established and modem algorithms, as well as a contemporary user interface to facilitate the application by clinical investigators. In addition, the software and documentation will be freely accessible for research purposes. To meet these goals, we intend to upgrade our existing software to utilize a modern user interface in the framework of MS-Windows NT/2000/XP operating system (Aim 1). Inclusion of contemporary algorithms. (Aim 2) will expand the software capabilities and provide more precision, additional information, and increased user functionality. Special emphasis will be placed on improving the raw data preprocessing techniques (Aim 3), and on validation and testing of the new algorithms with simulated and experimental data (Aim 5). Extensive documentation will be created to ensure proper understanding and usage of the software and to facilitate future modifications by us and/or other investigators (Aim 4). The software and documentation will be available as we expand our World Wide Web presence (Aim 6). Improving and expanding our annual "Workshop on the Analysis of Hormone Pulsatility". (Aim 7) will further popularize the software package and supply essential feedback. This effort will provide the endocrine research community with contemporary, easy-to-use, computer- based tools for studying, individually or jointly, various characteristics of a single or multiple related hormone concentration-time series. We also envision potential applications in other non-endocrine research fields.

描述（由申请人提供）：该提案将通过进一步开发，扩展，验证和分配数据分析算法和软件在过去二十年中创建的数据分析算法和软件来创建一个集成软件包，以调查激素浓度时间序列。这些程序探讨了许多神经内分泌和外周分泌激素的血清浓度谱的典型的上流波动。广泛的实验和理论工作记录了这些波动的生理重要性，这些波动可能会因病理生理学而改变，或者可以介导关键的关键内部和间隙区分。但是，我们当前的程序无法充分解决内分泌研究人员的不断发展的需求，这些程序基于过时的计算机平台，用户界面以及缺乏广泛的文档。因此，我们建议开发一个集成的高级数据分析算法，随之而来的软件和文档，以对内分泌浓度时间序列进行多方面研究。该套件将涵盖已建立和调制解调器算法以及当代用户界面，以促进临床研究人员的应用。此外，用于研究目的的软件和文档将可以自由访问。为了实现这些目标，我们打算升级现有软件以在MS-Windows NT/2000/XP操作系统的框架中利用现代用户界面（AIM 1）。包括当代算法。 （AIM 2）将扩展软件功能，并提供更精确，附加信息和增加的用户功能。特别重点将放在改进原始数据预处理技术（AIM 3），以及使用模拟和实验数据的新算法验证和测试（AIM 5）上。将创建广泛的文档，以确保对软件的适当理解和使用，并促进我们和/或其他研究人员的未来修改（AIM 4）。当我们扩大万维网的影响力时，该软件和文档将提供（AIM 6）。改善和扩展我们的年度“关于激素搏动性分析的研讨会”。 （AIM 7）将进一步普及软件包，并提供基本的反馈。这项工作将为内分泌研究社区提供当代，易于使用的基于计算机的基于计算机的工具，用于研究单个或多个相关激素浓度时间系列的各种特征。我们还设想在其他非内分泌研究领域的潜在应用。