The Biochemistry and Cell Biology of Metabolic Diseases

代谢疾病的生物化学和细胞生物学

• 批准号: 6914199
• 负责人: CRAIG C MALBON
• 金额: $ 34.8万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-14 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6914199
• 关键词: Biochemistry; Cell; Biology; Metabolic; Diseases

DESCRIPTION (provided by applicant): The institutional NRSA program sponsored by the Diabetes & Metabolic Diseases Research Center (DMDRC) offers multidisciplinary post-graduate training opportunities to the scientifically-trained (Ph.D.) and clinically-trained (M.D.) to acquire expertise in the study of metabolic diseases using state-of-the-art approaches of biochemistry, cell and molecular biology. Opportunities for training include diabetes & insulin action, protein metabolism, G-protein-coupled receptor action in disease states, cell signaling, Ras and MAP kinase regulation. Expertise is derived from 27 trainers from 9 departments with basic/clinical research in 5 major disciplines (physiology, pharmacology, biochemistry, molecular biology & cell biology). The training faculty support the tenet that a successful research career in the diverse and multifaceted area of endocrine and metabolic diseases requires a broadly-based background founded in these five major disciplines as well as a hybrid perspective which is receptive to strategies transcending the limits of one's immediate specialty. Training is principally as participants in vigorous, supportive research programs of individual trainers as well as more-broadly-based training as DMDRC members. Trainees actively participate in weekly interdepartmental seminars, minisymposia, journal clubs in specialized areas (endocrinology, cell signaling), and periodic scientific meetings where reports on original research are presented. The trainees (8 per year) will be principally medical (M.D.) or Ph.D. graduates who demonstrate a keen interest in taking advantage of these opportunities. Emphasis is placed on the vigorous recruitment of women and underrepresented minorities. Trainees are selected based upon their ability to conduct original research in a careful and critical manner, the nature and quality of their thesis and/or prior work, and recommendations by referees. Competitive applicants visit the campus and present a seminar. Facilities include modem laboratories (>80,000 n.s.f.) equipped for original research endeavors. Unique opportunities exist for advanced training in transgenic and KO mice use, molecular biology, proteomics (MALDI and QToF mass spectrometry) & structural biology, microscopy & imaging analysis, DNA microarray, and iRNA use. The DMDRC T32 program sponsors bioethics training, career building, and planning. The DMDRC training program enjoys strong University-wide support.

描述（由申请人提供）： 由糖尿病和代谢疾病研究中心（DMDRC）赞助的机构NRSA计划为经过科学培训（Ph.D.）和临床培训（M.D.）提供了多学科的研究生培训机会，可在使用Temabolic疾病的研究中获取临床疾病的专业知识。训练的机会包括糖尿病和胰岛素作用，蛋白质代谢，疾病状态中的G蛋白偶联受体作用，细胞信号传导，RAS和MAP激酶调节。专业知识来自来自9个主要学科的基础/临床研究的27个培训师（生理学，药理学，生物化学，分子生物学和细胞生物学）。培训学院支持宗旨是，在内分泌和代谢疾病的多样化和多方面领域的成功研究职业需要建立在这五个主要学科中的广泛基础背景以及混合视角，该背景可以接受，这些策略可以超越直接特殊特殊的局限性策略。培训主要是作为个别培训师的剧烈，支持性研究计划的参与者以及DMDRC成员的基于更宽敞的培训。学员积极参加每周的跨部门研讨会，迷你典礼，专业领域的期刊俱乐部（内分泌学，细胞信号传导）和定期科学会议，其中介绍了有关原始研究的报告。学员（每年8名）将主要是医学（M.D.）或博士学位。对利用这些机会表现出浓厚兴趣的毕业生。重点放在妇女和代表性不足的少数民族中的剧烈招募。基于学员以谨慎和批判的方式进行原始研究的能力，论文和/或先前工作的性质和质量以及裁判的建议。有竞争力的申请人参观校园并举行研讨会。设施包括配备原始研究工作的现代实验室（> 80,000 N.S.F.）。具有转基因和KO小鼠使用，分子生物学，蛋白质组学（MALDI和QTOF质谱法）和结构生物学，显微镜和成像分析，DNA微阵列和IRNA的使用的独特机会。 DMDRC T32计划赞助生物伦理学培训，职业建设和计划。 DMDRC培训计划享有强有力的大学范围内的支持。