Femtosecond source for multiphoton endoscopy in cancer

用于癌症多光子内窥镜检查的飞秒源

• 批准号: 6923726
• 负责人: CHRIS XU
• 金额: $ 20.27万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6923726
• 关键词: biomedical device power system; biomedical equipment development; electromagnetic radiation; electron optics; endoscopy; fiber optics; health science research; laboratory mouse; neoplasm /cancer radiodiagnosis

DESCRIPTION (provided by applicant) The goal of this research program is to demonstrate a fiber-integrated, compact, high power, and electronically controlled femtosecond system at 780 nm, which is specifically designed for multiphoton endoscopic imaging for cancer detection and diagnostics. The research activities will explore the concept and devices for generating femtosecond pulses using active electro-optic phase modulation in a loop configuration. The proposed approach is dramatically different from the common mode-locking techniques and uses entirely linear optics, enabling adjustable pulse repetition rate and pulse width. The chirp of the output pulse can be electronically tuned to compensate the linear dispersion of several meters of optical fiber, allowing fiber delivery of femtosecond pulses without the cumbersome free-space grating pairs. Leveraging the highly mature and integrated techniques that have been developed for the telecommunications industry, the proposed research efforts will create "telecom grade" femtosecond sources that are truly robust and turn-key, and tailored specifically for in vivo endoscopic imaging. Such sources will be essential for the practical implementation of multiphoton endoscopy for cancer research, particularly to biomedical experts that are not trained in lasers and optics. The proposed research involves close collaboration between Cornell University (the PI and Co-PI Warren Zipfel) and electro-optic device innovator Dr. Suwat Thaniyavarn of EOSPACE Inc. (Redmond, WA.). The three specific aims are: 1. Design and fabricate an integrated electro-optical loop for spectrum generation. 2. Design and fabricate a fiber-integrated femtosecond system at 780 nm. 3. Demonstrate the significance of this new femtosecond source for multiphoton endoscopic imaging for cancer research. The industry-academia collaboration established by this program strongly couples biomedical imaging and the fiber-optic communication industry, creating great synergies between two seemly divergent fields and providing new opportunities for innovation in biomedical imaging.

描述（由申请人提供） 该研究计划的目的是证明780 nm处的纤维集成，紧凑，高功率和电子控制的飞秒系统系统，该系统是专门为多光子内窥镜成像设计的，用于癌症检测和诊断。研究活动将探索使用循环配置中主动的电光相调制生成飞秒脉冲的概念和设备。所提出的方法与通用模式锁定技术截然不同，并使用了完全线性光学元件，从而实现了可调节的脉冲重复率和脉冲宽度。可以通过电子调整输出脉冲的鸣叫，以补偿几米光纤的线性分散体，从而使飞秒脉冲的纤维传递，而无需麻烦的自由空间光栅对。 拟议的研究工作利用为电信行业开发的高度成熟和集成的技术，将创建“电信等级”的飞秒来源，这些资源确实是强大而弯曲的，并专门针对体内内镜成像量身定制。此类来源对于用于癌症研究的多光子内窥镜检查的实际实施至关重要，特别是对于未接受激光和光学培训的生物医学专家。拟议的研究涉及康奈尔大学（PI和Co-Pi Warren Zipfel）与Eospace Inc.的Suwat Thaniyavarn博士（华盛顿州雷德蒙德）之间的密切合作。 三个具体目标是： 1。设计和制造一个集成的电流环，以生成光谱。 2。设计和制造一个在780 nm处的纤维综合系统。 3。证明了这种新的飞秒多秒源对癌症研究中多光子内窥镜成像的重要性。 该计划建立的行业 - academia合作强烈融合了生物医学成像和光纤通信行业，在两个看似不同的领域之间创造了出色的协同作用，并为生物医学成像中的创新提供了新的机会。