Femtosecond source for multiphoton endoscopy in cancer

用于癌症多光子内窥镜检查的飞秒源

• 批准号: 6923726
• 负责人: CHRIS XU
• 金额: $ 20.27万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6923726
• 关键词: biomedical device power system; biomedical equipment development; electromagnetic radiation; electron optics; endoscopy; fiber optics; health science research; laboratory mouse; neoplasm /cancer radiodiagnosis

DESCRIPTION (provided by applicant) The goal of this research program is to demonstrate a fiber-integrated, compact, high power, and electronically controlled femtosecond system at 780 nm, which is specifically designed for multiphoton endoscopic imaging for cancer detection and diagnostics. The research activities will explore the concept and devices for generating femtosecond pulses using active electro-optic phase modulation in a loop configuration. The proposed approach is dramatically different from the common mode-locking techniques and uses entirely linear optics, enabling adjustable pulse repetition rate and pulse width. The chirp of the output pulse can be electronically tuned to compensate the linear dispersion of several meters of optical fiber, allowing fiber delivery of femtosecond pulses without the cumbersome free-space grating pairs. Leveraging the highly mature and integrated techniques that have been developed for the telecommunications industry, the proposed research efforts will create "telecom grade" femtosecond sources that are truly robust and turn-key, and tailored specifically for in vivo endoscopic imaging. Such sources will be essential for the practical implementation of multiphoton endoscopy for cancer research, particularly to biomedical experts that are not trained in lasers and optics. The proposed research involves close collaboration between Cornell University (the PI and Co-PI Warren Zipfel) and electro-optic device innovator Dr. Suwat Thaniyavarn of EOSPACE Inc. (Redmond, WA.). The three specific aims are: 1. Design and fabricate an integrated electro-optical loop for spectrum generation. 2. Design and fabricate a fiber-integrated femtosecond system at 780 nm. 3. Demonstrate the significance of this new femtosecond source for multiphoton endoscopic imaging for cancer research. The industry-academia collaboration established by this program strongly couples biomedical imaging and the fiber-optic communication industry, creating great synergies between two seemly divergent fields and providing new opportunities for innovation in biomedical imaging.

描述（由申请人提供） 该研究项目的目标是展示一种光纤集成、紧凑、高功率、电子控制的 780 nm 飞秒系统，该系统专为用于癌症检测和诊断的多光子内窥镜成像而设计。研究活动将探索在环路配置中使用有源电光相位调制生成飞秒脉冲的概念和设备。所提出的方法与常见的锁模技术显着不同，并且使用完全线性光学器件，从而能够调节脉冲重复率和脉冲宽度。输出脉冲的啁啾可以通过电子方式调谐，以补偿几米光纤的线性色散，从而允许光纤传输飞秒脉冲，而无需繁琐的自由空间光栅对。 利用为电信行业开发的高度成熟的集成技术，拟议的研究工作将创建真正强大且交钥匙的“电信级”飞秒源，并专门为体内内窥镜成像量身定制。这些来源对于癌症研究中多光子内窥镜的实际实施至关重要，特别是对于没有接受过激光和光学培训的生物医学专家而言。拟议的研究涉及康奈尔大学（首席研究员和联合首席研究员 Warren Zipfel）与 EOSPACE Inc.（华盛顿州雷德蒙德）的电光器件创新者 Suwat Thaniyavarn 博士之间的密切合作。 这三个具体目标是： 1. 设计和制造用于光谱生成的集成电光环路。 2. 设计并制造780 nm 光纤集成飞秒系统。 3. 证明这种新的飞秒源对于多光子内窥镜成像对于癌症研究的重要性。 该项目建立的产学合作将生物医学成像和光纤通信行业紧密结合起来，在两个看似不同的领域之间产生了巨大的协同效应，并为生物医学成像的创新提供了新的机遇。