Understanding the origin and evolutionary history of plant immunity

了解植物免疫的起源和进化历史

• 批准号: 2584915
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2584915
• 关键词: Understanding; origin; evolutionary; history; plant

The fossil record demonstrates that filamentous microbes invaded ancient plant cells with intracellular hyphal structures over 450 million years ago. To this day, a rich diversity of extant land plant taxa continues to be colonized by detrimental and beneficial microbes, yet much of our knowledge has focused on the evolutionarily young angiosperm lineage of flowering plants. To better understand how distantly-related land plants defend themselves against pathogen infection, the research group investigates the molecular genetic mechanisms controlling disease resistance in the model liverwort Marchantia polymorpha. In particular, focusing on interactions with fungus-like filamentous oomycete phytopathogens belonging to the genus Phytophthora, which provide a unique platform to compare host responses to infection across distantly-related land plant lineages.The goal of this project is to investigate the origin and evolutionary history of nonhost resistance strategies that protect the model liverwort M. polymorpha from Phytophthora infection. Using comparative macroevolutionary, molecular genetic, and multi-omics approaches, widely-conserved and lineage-specific aspects of plant defence will be explored that will ultimately inform future efforts to protect crops from harmful pathogens.

化石记录表明，丝状微生物在 4.5 亿年前就侵入了具有细胞内菌丝结构的古代植物细胞。直到今天，丰富多样的现存陆地植物类群继续被有害和有益的微生物定殖，但我们的大部分知识都集中在开花植物的进化上年轻的被子植物谱系上。为了更好地了解远缘陆地植物如何防御病原体感染，研究小组研究了控制模型地钱地钱抗病性的分子遗传机制。特别是，重点关注与属于疫霉属的类似真菌的丝状卵菌植物病原体的相互作用，这提供了一个独特的平台来比较宿主对远亲陆地植物谱系感染的反应。该项目的目标是研究起源和进化保护模型地钱免受疫霉感染的非宿主抗性策略的历史。使用比较宏观进化、分子遗传学和多组学方法，将探索植物防御的广泛保守和谱系特异性方面，这最终将为未来保护作物免受有害病原体侵害的努力提供信息。