Dietary Protein Effect on Bone Mass, Loss and Fracture

膳食蛋白质对骨量、骨损失和骨折的影响

• 批准号: 7018247
• 负责人: Marian T. Hannan
• 金额: $ 27.37万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7018247
• 关键词: accidental falls; bone density; bone fracture; clinical research; dietary proteins; hip fractures; human data; longitudinal human study; nutrition related tag; osteoporosis; pathologic bone resorption; spine

DESCRIPTION (provided by applicant): Almost 30 million Americans are affected by osteoporosis with over 1.8 million osteoporotic fractures occurring each year, and these figures will increase significantly as the American population ages. Nutritional intake is known to affect bone and is a potentially modifiable factor. Traditionally, calcium and vitamin D have been the focus in most nutrition studies addressing bone health. As such, relatively little is known about the role of dietary protein on skeletal health. We propose to examine dietary protein and age- related bone loss from different skeletal sites. Dietary factors represent an important understudied area in osteoporosis and this work will allow us to better understanding ways to preserve bone as well as insights into the possible mechanisms for a protein influence on bone mineral density (BMD). This study proposes to examine associations between dietary protein and bone mass, longitudinal bone loss of the hip and spine, falls and hip fracture over 8-13 year follow-up among the population-based Framingham Cohort. Specifically, using a well-characterized cohort, the 4 specific aims of this study will examine the possible pathway between dietary protein intakes and skeletal health via: 1) BMD, 2) bone loss, 3) lean mass and falls, and 4) hip fracture. The richness of the data collected by the Framingham Study will also permit us to examine other factors that may be on the pathway between dietary protein intake and bone health. This project will make extensive use of the resources and data already collected from previous Framingham grants. Thus, by leveraging these data resources, our proposed study will be able to achieve its goals at lower cost, and extend the investigation of nutritional influences upon bone into important new areas that were previously unexplored. The proposed study will provide essential information on associations of keen interest both to clinical medicine and public health. Better understanding of potentially modifiable factors such as dietary protein may help us make more reliable public health interventions targeted at preserving bone. Bone loss and osteoporosis are serious burdens for many older individuals. This study will provide insights on potential mechanisms to reduce osteoporotic risks. Based on strong preliminary data, this study will provide new and important information about the role of dietary protein upon bone outcomes in older men and women. Dietary factors are poorly understood, yet potentially modifiable. More information is needed on the precise effects of dietary protein on bone health for community-based men and women.

描述（由申请人提供）：近3000万美国人受到骨质疏松症的影响，每年发生超过180万个骨质疏松性骨折，随着美国人口年龄的增长，这些数字将大大增加。众所周知，营养摄入会影响骨骼，是一个潜在的可修改因素。传统上，钙和维生素D是大多数针对骨骼健康的营养研究的重点。因此，关于饮食蛋白在骨骼健康中的作用相对较少。我们建议检查不同骨骼部位的饮食蛋白和与年龄相关的骨质丧失。饮食因素代表了骨质疏松症中重要的研究领域，这项工作将使我们能够更好地理解保存骨骼的方法以及对蛋白质对骨矿物质密度（BMD）影响的可能机制的见解。这项研究建议检查饮食蛋白和骨骼质量，臀部和脊柱的纵向骨质损失，基于人口的弗雷明汉同龄人的8 - 13年随访中的跌落和髋部骨折。具体而言，使用特征良好的队列，这项研究的4个特定目的将通过以下方法检查饮食蛋白摄入量和骨骼健康之间的可能途径：1）BMD，2）骨骼损失，3）瘦质量和跌倒，以及4）髋部骨折。 Framingham研究收集的数据的丰富度还将使我们能够检查饮食蛋白摄入和骨骼健康之间可能存在的其他因素。该项目将广泛使用以前的弗雷明厄姆赠款中收集的资源和数据。因此，通过利用这些数据资源，我们提出的研究将能够以较低的成本实现其目标，并将营养影响的研究扩展到以前未经探索的重要新领域。 拟议的研究将提供有关临床医学和公共卫生兴趣关联的基本信息。更好地了解可能修改的因素，例如饮食蛋白质，可能有助于我们使针对保存骨骼的更可靠的公共卫生干预措施。对于许多老年人来说，骨质流失和骨质疏松症是严重的负担。这项研究将提供有关降低骨质疏松风险的潜在机制的见解。基于强大的初步数据，这项研究将提供有关饮食蛋白在老年男性和女性骨骼结局的作用的新的重要信息。饮食因素知之甚少，但可能可修改。需要更多信息，了解饮食蛋白对社区男性和女性骨骼健康的确切影响。