SMALL SAMPLE METHODOLOGY FOR DRUG USE RESEARCH

药物使用研究的小样本方法

• 批准号: 6999014
• 负责人: TAMMY ROOT
• 金额: $ 3.47万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999014
• 关键词: adolescence (12-20); anorexia; behavioral /social science research tag; bulimia nervosa; clinical research; comorbidity; data collection methodology /evaluation; eating disorders; female; human data; longitudinal human study; mathematical model; mental health epidemiology; predoctoral investigator; sample collection; statistics /biometry; substance abuse epidemiology; women' s health

DESCRIPTION (provided by applicant): The comorbidity of substance use and eating disorders is emerging as a serious problem affecting adolescent girls (Foster & Richter, 2003). How this comorbidity develops is not well understood. Investigators wishing to study this phenomenon are faced with small samples, which create problems for some statistical techniques that could be tremendously useful. For example, latent transition analysis (LTA) has been used extensively to model the development of substance use (Collins & Wulgalter, 1992). LTA provides a promising framework for testing models that place development of eating disorders within the context of substance use. However, currently, LTA is not suitable for samples as small as those typically found in eating disorder research. The two aims of the proposed project are: (1) to develop and test a small sample version of LTA using a Bayesian approach, and (2) informed by the results from using Aim #1, investigate differential patterns of substance use among adolescent females with and without eating disorders. Products will include peer-reviewed scientific publications on the comorbidity of substance use and eating disorders, Bayesian methods in general, and on the new version of LTA for use in other drug use research applications.

描述（由申请人提供）： 药物滥用和饮食失调的共病正在成为影响青春期女孩的一个严重问题（Foster & Richter，2003）。这种合并症是如何发展的尚不清楚。希望研究这种现象的研究人员面临着小样本，这给一些可能非常有用的统计技术带来了问题。例如，潜在转变分析 (LTA) 已被广泛用于模拟物质使用的发展（Collins & Wulgalter，1992）。 LTA 为测试模型提供了一个有前景的框架，将饮食失调的发展置于物质使用的背景下。然而，目前 LTA 并不适合饮食失调研究中常见的小样本。拟议项目的两个目标是：(1) 使用贝叶斯方法开发和测试 LTA 的小样本版本，以及 (2) 根据目标 #1 的结果，调查青春期女性物质使用的差异模式有或没有饮食失调。产品将包括有关物质使用和饮食失调的共病、一般贝叶斯方法以及用于其他药物使用研究应用的新版本 LTA 的同行评审科学出版物。