SMALL SAMPLE METHODOLOGY FOR DRUG USE RESEARCH

药物使用研究的小样本方法

• 批准号: 7268954
• 负责人: TAMMY ROOT
• 金额: $ 0.02万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-09-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7268954
• 关键词: Address; Affect; Alcohol or Other Drugs use; Anorexia; Bayesian Method; Behavior; Bulimia; Comorbidity; Data; Data Set; Development; Diagnosis; Drug usage; Eating Disorders; Fellowship; Female Adolescents; Fostering; Individual; Low Prevalence; Methodology; Methods; Modeling; Names; Pattern; Peer Review; Plant Roots; Prevention; Procedures; Publications; Purpose; Rate; Research; Research Personnel; Sampling; Science; Scientist; Techniques; Testing; model development

DESCRIPTION (provided by applicant): The comorbidity of substance use and eating disorders is emerging as a serious problem affecting adolescent girls (Foster & Richter, 2003). How this comorbidity develops is not well understood. Investigators wishing to study this phenomenon are faced with small samples, which create problems for some statistical techniques that could be tremendously useful. For example, latent transition analysis (LTA) has been used extensively to model the development of substance use (Collins & Wulgalter, 1992). LTA provides a promising framework for testing models that place development of eating disorders within the context of substance use. However, currently, LTA is not suitable for samples as small as those typically found in eating disorder research. The two aims of the proposed project are: (1) to develop and test a small sample version of LTA using a Bayesian approach, and (2) informed by the results from using Aim #1, investigate differential patterns of substance use among adolescent females with and without eating disorders. Products will include peer-reviewed scientific publications on the comorbidity of substance use and eating disorders, Bayesian methods in general, and on the new version of LTA for use in other drug use research applications.

描述（由申请人提供）： 物质使用和饮食失调的合并症正成为影响青少年女孩的严重问题（Foster＆Richter，2003年）。这种合并症的发展方式尚未得到很好的理解。希望研究这种现象的研究人员面临小样本，这为某些可能非常有用的统计技术造成了问题。例如，潜在过渡分析（LTA）已广泛用于建模物质使用的发展（Collins＆Wulgalter，1992）。 LTA为测试模型提供了一个有希望的框架，该模型将饮食失调的发展放置在药物使用的背景下。但是，目前，LTA不适合像饮食失调研究中通常发现的样品一样小。拟议项目的两个目的是：（1）使用贝叶斯方法开发和测试LTA的小样本版本，（2）（2）通过使用AIM＃1的结果告知，请研究具有和没有饮食障碍的青少年女性中物质使用的差异模式。产品将包括有关药物使用和饮食失调合并症的同行评审科学出版物，一般的贝叶斯方法以及用于其他药物使用研究应用程序的新版本的LTA。