CORE--CHEMISTRY AND PET IMAGING

核心——化学和宠物成像

• 批准号: 6949812
• 负责人: JORGE R BARRIO
• 金额: $ 20.53万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6949812
• 关键词: aging; bioimaging /biomedical imaging; biomedical facility; chemical synthesis; dementia; drug design /synthesis /production; genetically modified animals; human subject; laboratory mouse; laboratory rat; molecular probes; particle accelerators; positron emission tomography; radionuclides; radiotracer; small molecule

The Chemistry and PET Imaging Core will use the resources of two technical centers in the UCLA PET program: the Molecular Imaging Probe Production and the PET Imaging Instrumentation. The Molecular Imaging Probe Production Technical Center is responsible for the production of all the radiopharmaceuticals for the project included in this application. A wide range of products labeled with O-15, N-13, C-11 and F-18 are routinely synthesized, purified and provided to various investigators under a variety of different protocols. This Technical Center continually explores new radioisotope production techniques, new precursor syntheses and new radiolabeled reagents. It also focuses its activities in improvement of the radiochemical yields of established methods, new automated radiosynthesis modules and ways to reduce personal radiation exposures. For this Program Project grant the Technical Center will provide [18F]FDG, [18F]FDDNP and [18F]MPPF. The PET Imaging Instrumentation Core provides and supports the imaging instruments used by all Program investigators. It ensures that all instruments are maintained and kept in good running order and performs the periodic daily/monthly quality contol. It also educates investigators about the capabilities and limitations of the instruments and assists them in planning and executing their experiments. It ensures the quantitative accuracy of their measurements (wherever applicable) and in collaboration with the Computation and Modeling Tech Center (Image Analysis Core: Sung Cheng Huang, Core Leader) guides investigators in their data interpretation. In addition it ensures the proper data archival and storage, as well as compliance of investigators with all local, state and federal regulations governing molecular imaging research with animals and humans. This Core will provide and maintain the necessary tomographic and ancillary equipment and resources to perform human PET and microPET scans proposed in this grant application; perform periodic quality controls; implement and maintain detailed logs of all the operations; coordinate, schedule and optimize the use of all the tomographs and ancillary equipment (i.e. gamma counters) necessary in this application with the cyclotron production of short-lived molecular imaging probes; maintain and upgrade tomographic equipment and computer systems for data collection, image reconstruction and transfer; assist investigators in planning and performing studies with the imaging systems, including compliance with all local, state and federal regulations to conduct biological imaging research with animals and humans.

化学和宠物成像核心将在UCLA PET计划中使用两个技术中心的资源：分子成像探针生产和PET成像仪器。分子成像探针生产技术中心负责本应用程序中包含的项目的所有放射性药物的生产。在各种不同的方案下，通常将带有O-15，N-13，C-11和F-18标记的广泛产品经常合成，纯化并提供给各种研究人员。该技术中心不断探索新的放射性同位素生产技术，新的前体合成和新的放射性标记试剂。它还将其活动重点放在改善已建立方法的放射化学产量，新的自动放射合成模块以及减少个人辐射暴露的方法上。对于此计划项目，技术中心将提供[18F] FDG，[18F] FDDNP和[18F] MPPF。宠物成像仪器核心提供并支持所有程序研究人员使用的成像仪器。它确保所有仪器都保持良好的运行顺序，并执行定期的每日/每月质量抑制。 它还向调查人员教育了工具的功能和局限性，并协助他们计划和执行实验。它确保其测量值（无论在任何地方）以及与计算和建模技术中心（图像分析核心：sung sung cheng cheng，核心负责人）的定量准确性指导研究人员的数据解释。此外，它确保了适当的数据档案和存储，以及调查人员与所有地方，州和联邦法规的遵守 与动物和人类进行成像研究。该核心将提供并维护必要的层析成像和辅助设备和资源，以进行本赠款应用中提出的人类宠物和微型扫描；执行定期质量控制；实施并维护所有操作的详细日志；在此应用中，与短寿命分子成像探针产生的所有层状设备和辅助设备（即伽玛计数器）的使用（即伽马计数器）进行协调，安排和优化；维护和升级层析成像设备和计算机系统，以收集数据，图像重建和传输；协助 研究人员在计划和进行成像系统研究中进行研究，包括遵守所有地方，州和联邦法规，以对动物和人类进行生物成像研究。