High Field MRI For Optimized Translational 1H Multiparametric and Multinuclear Imaging Research

用于优化平移 1H 多参数和多核成像研究的高场 MRI

• 批准号: 10175910
• 负责人: John Kurhanewicz
• 金额: $ 200万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2024-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175910
• 关键词: 2,4-Dinitrophenol; Address; Aging; Award; Basic Science; Biomedical Research; Brain Diseases; Clinical; Clinical Research; Communicable Diseases; Communities; Deuterium; Diabetes Mellitus; Educational workshop; Equipment; Extramural Activities; Funding; Goals; Grant; Heart Diseases; Human Resources; Image; Individual; Information Dissemination; Infrastructure; International; Internet; Liver diseases; Magnetic Resonance Imaging; Mus; Oncology; Pharmacy facility; Phosphorus; Principal Investigator; Rattus; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Site; Students; Techniques; Technology; Training; United States National Institutes of Health; Visit; bioimaging; cost; drug discovery; experience; faculty support; imaging capabilities; imaging study; instrument; instrumentation; investigator training; medical schools; pre-clinical; preclinical imaging; programs; radiological imaging; spectroscopic imaging; student training; symposium; web site

Project Summary/Abstract The proposed replacement of a unique but aging, commercially unsupported, mouse only vertical bore Varian 14T pre-clinical MRI to a state-of-the-art Bruker 9.4T horizontal bore MRI scanner large enough for mice and rats is justified by the research needs of 23 currently funded projects (21 NIH grants) in translational and clinical biomedical research at UCSF and internationally through the NIH P41 supported Hyperpolarized MRI Technology Resource Center. This S10 HEI award is critical to enable the replacement of aging pre-clincial MRI to state-of-the-art, by addressing current limitations facing funded and new research projects. This application is supported by strong institutional support covering ≈ 1/3 of the cost and siting of the 9.4T MRI scanner, and a Justification of Need which not only includes strong research support but also substantial training, a well- established administrative infrastructure through the UCSF Research Resource Program’s (RRP) Pre-clinical Imaging Core, and the UCSF Hyperpolarized MRI Technology Resource Center (HMTRC). The RRP core and HMTRC provide the highly experienced technical support, training, expert personnel, ancillary equipment and infrastructure for dissemination of results/techniques to make this major high-end instrumentation project optimally successful in its goal to provide state-of-the-art instrumentation to both intra- and extramural users. The UCSF RRP Pre-Clinical Imaging Core, where the 9.4T MRI will be sited, provides advanced pre-clinical imaging instrumentation consisting of 4 scanners, 2 DNP polarizers, other supporting small equipment, wet lab facilities, as well as expert personnel for translational pre-clinical imaging research for the entire UCSF campus. Specifically, the Pre-clinical Imaging Core serves a broad research and clinical community (50+ Principal Investigators in the Schools of Medicine and Pharmacy) and supports a broad spectrum of basic and clinical research (oncology, diabetes, cardiac disease, brain disorders, liver disease, infectious diseases and drug discovery). The equipment will be used for training a large number of students at UCSF either as part of formal graduate courses or research projects. Furthermore, this instrument will also be used to train investigators from around the world through the UCSF Hyperpolarized MRI Technology Resource Center as well as junior faculty supported by the Department of Radiology and Biomedical Imaging. The new pre-clinical MRI will provide critically-needed, expanded pre-clinical MR imaging capabilities by providing the ability to do larger rodent studies, and by using hardware enhancements to go in exciting new directions such as deuterium and phosphorus spectroscopic imaging studies. In summary, this equipment replacement S10 proposal is critical to remove a major bottleneck limiting pre-clinical MRI research and will also benefit the training of students at UCSF and external investigators nationally and internationally through hands-on workshops, individual visits, web-conferences, website dissemination, and collaborative multi-site research.

项目概要/摘要 提议更换独特但老化、没有商业支持的、仅限鼠标的垂直孔瓦里安 14T 临床前 MRI 到最先进的 Bruker 9.4T 水平孔 MRI 扫描仪，其尺寸足以容纳小鼠和 23 个目前资助的转化和临床项目（21 个 NIH 拨款）的研究需求证明了大鼠的合理性 通过 NIH P41 支持的超极化 MRI 在 UCSF 和国际上进行生物医学研究 技术资源中心。S10 HEI 奖项对于替代老化的临床前 MRI 至关重要。 通过解决当前受资助的新研究项目面临的限制，达到最先进的水平。 得到强大机构支持的支持，涵盖 9.4T MRI 扫描仪成本和安装的 ≈ 1/3，以及 需求理由不仅包括强有力的研究支持，还包括大量培训，这是一个良好的 通过 UCSF 研究资源计划 (RRP) 的临床前建立了行政基础设施 成像核心和 UCSF 超极化 MRI 技术资源中心 (HMTRC)。 HMTRC 提供经验丰富的技术支持、培训、专家人员、辅助设备和 用于传播成果/技术的基础设施，以完成这一重大高端仪器项目 为校内和校外用户提供最先进的仪器这一目标取得了最大的成功。 9.4T MRI 将位于 UCSF RRP 临床前成像核心，提供先进的临床前成像 成像仪器由4个扫描仪、2个DNP偏光镜、其他配套小型设备、湿实验室组成 整个加州大学旧金山分校校园的转化临床前成像研究的设施和专家人员。 具体来说，临床前成像核心服务于广泛的研究和临床社区（50 多个主要 医学和药学院的研究人员）并支持广泛的基础和临床研究 研究（肿瘤学、糖尿病、心脏病、脑部疾病、肝脏疾病、传染病和药物） 该设备将用于培训加州大学旧金山分校的大量学生，或者作为正式课程的一部分。 此外，该工具还将用于培训来自研究生课程或研究项目的研究人员。 通过 UCSF 超极化 MRI 技术资源中心以及初级教师在世界各地 新的临床前 MRI 将得到放射学和生物医学成像部门的支持。 通过提供更大的啮齿动物的能力来扩展急需的临床前 MR 成像能力 研究，并通过使用硬件增强功能进入令人兴奋的新方向，例如氘和 磷光谱成像研究。 综上所述，此次设备更换S10提案对于消除限制临床前的主要瓶颈至关重要 MRI 研究也将有利于加州大学旧金山分校学生和全国外部研究人员的培训 通过实践研讨会、个人访问、网络会议、网站传播和 多地点协作研究。