High Field MRI For Optimized Translational 1H Multiparametric and Multinuclear Imaging Research

用于优化平移 1H 多参数和多核成像研究的高场 MRI

• 批准号: 10175910
• 负责人: John Kurhanewicz
• 金额: $ 200万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2024-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175910
• 关键词: 2,4-Dinitrophenol; Address; Aging; Award; Basic Science; Biomedical Research; Brain Diseases; Clinical; Clinical Research; Communicable Diseases; Communities; Deuterium; Diabetes Mellitus; Educational workshop; Equipment; Extramural Activities; Funding; Goals; Grant; Heart Diseases; Human Resources; Image; Individual; Information Dissemination; Infrastructure; International; Internet; Liver diseases; Magnetic Resonance Imaging; Mus; Oncology; Pharmacy facility; Phosphorus; Principal Investigator; Rattus; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rodent; Site; Students; Techniques; Technology; Training; United States National Institutes of Health; Visit; bioimaging; cost; drug discovery; experience; faculty support; imaging capabilities; imaging study; instrument; instrumentation; investigator training; medical schools; pre-clinical; preclinical imaging; programs; radiological imaging; spectroscopic imaging; student training; symposium; web site

Project Summary/Abstract The proposed replacement of a unique but aging, commercially unsupported, mouse only vertical bore Varian 14T pre-clinical MRI to a state-of-the-art Bruker 9.4T horizontal bore MRI scanner large enough for mice and rats is justified by the research needs of 23 currently funded projects (21 NIH grants) in translational and clinical biomedical research at UCSF and internationally through the NIH P41 supported Hyperpolarized MRI Technology Resource Center. This S10 HEI award is critical to enable the replacement of aging pre-clincial MRI to state-of-the-art, by addressing current limitations facing funded and new research projects. This application is supported by strong institutional support covering ≈ 1/3 of the cost and siting of the 9.4T MRI scanner, and a Justification of Need which not only includes strong research support but also substantial training, a well- established administrative infrastructure through the UCSF Research Resource Program’s (RRP) Pre-clinical Imaging Core, and the UCSF Hyperpolarized MRI Technology Resource Center (HMTRC). The RRP core and HMTRC provide the highly experienced technical support, training, expert personnel, ancillary equipment and infrastructure for dissemination of results/techniques to make this major high-end instrumentation project optimally successful in its goal to provide state-of-the-art instrumentation to both intra- and extramural users. The UCSF RRP Pre-Clinical Imaging Core, where the 9.4T MRI will be sited, provides advanced pre-clinical imaging instrumentation consisting of 4 scanners, 2 DNP polarizers, other supporting small equipment, wet lab facilities, as well as expert personnel for translational pre-clinical imaging research for the entire UCSF campus. Specifically, the Pre-clinical Imaging Core serves a broad research and clinical community (50+ Principal Investigators in the Schools of Medicine and Pharmacy) and supports a broad spectrum of basic and clinical research (oncology, diabetes, cardiac disease, brain disorders, liver disease, infectious diseases and drug discovery). The equipment will be used for training a large number of students at UCSF either as part of formal graduate courses or research projects. Furthermore, this instrument will also be used to train investigators from around the world through the UCSF Hyperpolarized MRI Technology Resource Center as well as junior faculty supported by the Department of Radiology and Biomedical Imaging. The new pre-clinical MRI will provide critically-needed, expanded pre-clinical MR imaging capabilities by providing the ability to do larger rodent studies, and by using hardware enhancements to go in exciting new directions such as deuterium and phosphorus spectroscopic imaging studies. In summary, this equipment replacement S10 proposal is critical to remove a major bottleneck limiting pre-clinical MRI research and will also benefit the training of students at UCSF and external investigators nationally and internationally through hands-on workshops, individual visits, web-conferences, website dissemination, and collaborative multi-site research.

项目摘要/摘要 拟议的替代者替换了独特但老化的，商业上不受支持的鼠标，只有垂直钻孔 14T临床前MRI至最先进的布鲁克9.4T水平孔MRI扫描仪，足以容纳小鼠，并且 大鼠的研究需求是23个当前资助的项目（21 NIH赠款）的研究需求，而翻译和临床则是合理的。 UCSF的生物医学研究和通过NIH p41在国际上支持的超极化MRI 技术资源中心。该S10 HEI奖对于实现衰老前MRI的衰老至关重要 通过解决资助和新的研究项目面临的当前限制，以解决最先进的问题。此应用程序是 在9.4T MRI扫描仪的成本和坐姿的强大机构支持的支持下， 需要的理由，不仅包括强大的研究支持，还包括实质性的培训，一个很好的培训 通过UCSF研究资源计划（RRP）临床前建立的行政基础架构 成像核心和UCSF超极化MRI技术资源中心（HMTRC）。 RRP核心和 HMTRC提供了经验丰富的技术支持，培训，专家人员，辅助设备以及 传播结果/技术的基础架构，以制造这一主要的高端仪器项目 最佳成功的目标是为壁外用户和壁外用户提供最先进的仪器。 UCSF RRP临床前成像核心（9.4T MRI）提供了高级临床前 成像仪器由4个扫描仪，2个DNP极化器，其他支撑小型设备，湿实验室组成 设施以及整个UCSF校园的转化前成像研究的专家人员。 具体而言，临床前成像核心为广泛的研究和临床社区服务（50多个主要 医学和药学学院的研究人员）并支持大量基本和临床 研究（肿瘤学，糖尿病，心脏病，脑部疾病，肝病，传染病和药物 发现）。该设备将作为正式的一部分用于培训UCSF的大量学生 研究生课程或研究项目。此外，该工具还将用于培训 通过UCSF超极化MRI技术资源中心以及初级教师 得到放射学和生物医学成像系的支持。新的临床前MRI将提供 通过提供更大的啮齿动物的能力，急需的，扩展的临床前MR成像能力 研究，以及使用硬件增强功能朝着令人兴奋的新方向（例如氘和 磷光谱成像研究。 总而言之，该设备更换S10提案对于删除限制前临床的主要瓶颈至关重要 MRI研究，还将受益于UCSF和全国外部调查人员的学生的培训 通过动手研讨会，个人访问，网络会议，网站传播和 协作多站点研究。