Alzheimer's Disease Genes, Cellular Pathways and Therapies

阿尔茨海默病基因、细胞通路和治疗

• 批准号: 7001149
• 负责人: RUDOLPH Emile TANZI
• 金额: $ 1.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001149
• 关键词: Alzheimer' s disease; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common form of dementia in the elderly. Over the past two decades, studies of AD at the genetic, molecular, and cell biological level have revealed a host of genes, proteins, and biological pathways that impact on the pathogenesis of this disease. Characterization of these pathogenic pathways has suggested several promising therapeutic strategies for treating and preventing AD based on curbing the accumulation of the Abeta peptide in brain, regulating tau hyperphosphorylation, modulating inflammatory responses, and enhancing neurotransmitter function. This meeting will cover updates of the genetics of AD, Abeta generation and clearance pathways, regulation of tau, relevant animal models, novel therapeutic strategies, and advances in imaging and biomarkers for AD diagnosis. Alzheimer's disease (AD) and related disorders are the most common forms of dementia in the elderly population. The two greatest risk factors for AD are advancing age and family history. As the average lifespan continues to increase, particularly in the Western world, AD represents one of the single greatest burdens on the healthcare system. This symposium will focus on genetic risk factors, relevant cellular pathways and emerging therapies for AD and frontal temporal dementia.

描述（由申请人提供）：阿尔茨海默病（AD）是一种进行性神经退行性疾病，是老年人最常见的痴呆症。过去二十年来，在遗传、分子和细胞生物学水平上对 AD 的研究揭示了许多影响该疾病发病机制的基因、蛋白质和生物学途径。这些致病途径的表征提出了几种有前景的治疗和预防 AD 的治疗策略，其基础是抑制 Abeta 肽在大脑中的积累、调节 tau 过度磷酸化、调节炎症反应和增强神经递质功能。本次会议将涵盖 AD 遗传学的最新进展、Abeta 的生成和清除途径、tau 蛋白的调节、相关动物模型、新颖的治疗策略以及 AD 诊断的成像和生物标志物的进展。阿尔茨海默氏病 (AD) 和相关疾病是老年人群中最常见的痴呆症形式。 AD 的两个最大风险因素是年龄增长和家族史。随着平均寿命的不断延长，特别是在西方世界，AD 成为医疗保健系统最大的负担之一。本次研讨会将重点讨论 AD 和额颞叶痴呆的遗传风险因素、相关细胞途径和新兴疗法。