CBT/Comorbid Anxiety Disorders/Children/Asperger Syndro*

CBT/共病焦虑症/儿童/阿斯伯格综合症*

基本信息

批准号：
7015991
负责人：
Jeffrey James Wood
金额：
$ 7.73万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-23 至 2007-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Anxiety disorders are commonly diagnosed in children with Asperger syndrome (AS) and pervasive developmental disorder not otherwise specified (PDD-NOS). Anxiety disorders contribute to children's functional impairment over and above the functional deficits attributable to AS and PDD-NOS. Thus, investigators have called for the development of anxiety treatments for this population (Attwood, 2003). Cognitive behavioral therapy (CBT) has been found to be efficacious for anxiety disorders in typically developing children. This pilot study will advance the field by providing an estimate of the treatment effects of CBT for anxiety disorders among children with AS or PDD-NOS. The sample will include 20 children aged 7- 13 years with AS or PDD-NOS and a comorbid anxiety disorder. Children will be randomly assigned to immediate treatment or a 3-month waitlist. The manualized CBT program includes traditional anxiety treatment components including coping skills training (e.g., cognitive restructuring), in vivo exposure, operant procedures, and parent training. Additional treatment components have been added to enhance intervention response in children with AS or PDD-NOS, including emotion education, social skills/friendship skills training, and peer tutoring/mentoring modules. Trained graduate students with expertise in CBT and developmental disabilities will serve as therapists. Treatment fidelity will be checked using a session-by-session adherence checklist. Treatment acceptability and consumer satisfaction will be assessed at posttreatment, providing guidance on the extent to which the manual will need to be revised. Multiple measures of children's anxiety, including a structured diagnostic interview administered by an independent evaluator, will comprise the primary outcomes. Children's social functioning and service use will also be assessed to determine if CBT can affect relevant distal outcomes. By comparing outcomes for children in the immediate treatment group versus those in the waitlist group, we will estimate effect sizes of CBT for this population. Subsequently, power analyses will be conducted in planning for a larger clinical trial. This study could contribute to public health efforts to address the mental health needs of the rising number of children diagnosed with autism spectrum disorders. If CBT is found to be efficacious, it will be the first evidence-based psychological treatment to be successfully adapted for children with AS and PDD-NOS.

描述（由申请人提供）：焦虑症通常在阿斯伯格综合征（AS）和普遍性发育障碍的儿童中诊断出来（PDD-NOS）。焦虑症在归因于AS和PDD-NOS的功能缺陷之外，导致儿童的功能障碍。因此，研究人员呼吁为该人群开发焦虑治疗（Attwood，2003年）。认知行为疗法（CBT）已被发现在典型发展的儿童中对焦虑症有效。这项试点研究将通过估计CBT对AS或PDD-NOS儿童焦虑症的治疗效果的估计来推进该领域。该样本将包括20名7-13岁的儿童，患有AS或PDD-NOS和合并症焦虑症。儿童将被随机分配给立即治疗或3个月的候补名单。手动CBT计划包括传统的焦虑治疗组件，包括应对技能培训（例如认知重组），体内暴露，操作程序和家长培训。已经添加了其他治疗组件，以增强患有或PDD-NOS儿童的干预反应，包括情绪教育，社交技能/友谊技能培训以及同伴辅导/指导模块。具有CBT专业知识和发育障碍专业知识的训练有素的研究生将作为治疗师。治疗保真度将使用会议遵守清单检查。治疗可接受性和消费者满意度将在治疗后进行评估，并提供有关需要修改手册的程度的指导。儿童焦虑的多种措施，包括由独立评估者进行的结构化诊断访谈，将构成主要结果。还将评估儿童的社会功能和服务使用，以确定CBT是否会影响相关的远端结果。通过比较直接治疗组的儿童与候补名单组中的儿童的结果，我们将估计该人群的CBT效应大小。随后，将在规划更大的临床试验的计划中进行功率分析。这项研究可能有助于公共卫生努力，以满足诊断为自闭症谱系障碍的儿童数量增加的心理健康需求。如果发现CBT有效，它将是第一个基于证据的心理治疗方法，可以成功适应AS和PDD-NOS的儿童。