1/3 Treatment of Anxiety in Autism Spectrum Disorder

1/3 自闭症谱系障碍焦虑的治疗

• 批准号: 8631972
• 负责人: Jeffrey James Wood
• 金额: $ 22.37万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-16 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8631972
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent; Adverse effects; Affect; Aftercare; Age; Anxiety; Anxiety Disorders; Autacoids; Autistic Disorder; Behavior Therapy; Behavioral; Binding Sites; Characteristics; Child; Childhood; Cities; Clinical Services; Clinical Trials; Cognitive; Cognitive Therapy; Communities; Comorbidity; Data; Data Analyses; Diagnosis; Disadvantaged; Distress; Drug Interactions; Effect Modifiers (Epidemiology); Elements; Evidence based treatment; Felis catus; Florida; Frequencies; Friendships; Funding; Goals; Impairment; Individual; Institution; Intervention; Leadership; Link; Literature; Loneliness; Maintenance; Measures; Mediating; Mediator of activation protein; Mental Health; Mental disorders; Monitor; Outcome; Parents; Patients; Pharmaceutical Preparations; Poly(ADP-ribose) Polymerases; Population; Procedures; Protocols documentation; Public Health; Publications; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recruitment Activity; Recurrence; Relapse; Relative (related person); Research; Research Personnel; Resources; Schools; Services; Severities; Site; Social Functioning; Specific qualifier value; Structure; Symptoms; Syndrome; Testing; Training; Treatment Efficacy; Treatment Protocols; Treatment outcome; United States National Institutes of Health; Universities; Wood material; Work; Youth; alcohol use disorder; autism spectrum disorder; base; behavior observation; clinically significant; coping; data management; design; experience; flexibility; follow-up; functional outcomes; improved; meetings; programs; psychosocial; public health relevance; quality assurance; response; social; symposium; treatment adherence; treatment effect; treatment response; treatment site; trial comparing

Project Summary/Abstract Autism spectrum disorders (ASD) are common neurodevelopmental syndromes affecting 1% of U.S. children. Comorbid anxiety disorders affect 40 to 50% of children with ASD, causing substantial distress and impairment over and above that caused by ASD alone. High anxiety is associated with increased severity of ASD symptoms and social maladjustment in affected youth. Further, parents of children with ASD consider anxiety- related problems to be among the top two challenges facing their children. [Although standard practice cognitive-behavioral therapy (CBT) has been established as an efficacious and safe treatment for anxiety disorders among typically developing youth, its utility in comorbid cases with ASD remains unknown. To date, no studies have experimentally compared standard practice CBT to a cognitive-behavioral intervention that has been personalized for children with a comorbid presentation of anxiety and ASD.] This gap in the literature is of particular concern because there are no empirically-supported treatment options for youth with ASD and comorbid anxiety, and existing pharmacological interventions may have some disadvantages (e.g., limited efficacy in this population, side effects, and potential for drug x drug interactions). [Accordingly, we are proposing a randomized controlled trial to be conducted at three treatment sites to evaluate the efficacy of personalized CBT for anxiety in ASD (Behavioral Intervention for Anxiety in Children with Autism: BIACA) relative to standard practice CBT for anxiety (Coping Cat program). Over the last five years, the proposed BIACA intervention has been adapted and tailored to the characteristics and needs of high-functioning children with ASD; the Coping Cat program reflects the community standard that has been empirically supported in multiple NIH-funded trials.] In response to the NIH Roadmap Initiative, BIACA employs a modular treatment approach, allowing the intervention to be personalized to each youngster's unique needs. [Thus, the proposed research will: (1) examine the efficacy of BIACA relative to Coping Cat, which represents standard practice treatment, (2) evaluate the maintenance of treatment gains, (3) examine the impact of personalized intervention on functional outcomes such as social responsiveness, loneliness, and friendship quality, (4) test autism severity as a moderator of treatment outcome, and (5) explore other moderators and mediators of treatment outcome.] A total of 180 youth (ages 8-13 years) with ASD and co-occurring anxiety will be randomly assigned to one of the two treatment conditions. The three recruitment sites for this study are UCLA, the University of South Florida (USF), and Temple University. USF will provide data management services. Considering the rising number of children diagnosed with ASD together with the frequency and severity of comorbid anxiety, the proposed work is tailored to the unique needs of youth with ASD and will provide a timely contribution to public health efforts.

项目摘要/摘要 自闭症谱系障碍（ASD）是影响1％美国儿童的常见神经发育综合征。 合并症焦虑症会影响40％至50％的ASD儿童，造成严重的困扰和障碍 仅由ASD引起的超越。高焦虑与ASD严重程度增加有关 受影响青年的症状和社会疾病。此外，ASD儿童的父母考虑焦虑 - 相关问题是他们孩子面临的前两个挑战之一。 [虽然标准练习 认知行为疗法（CBT）已被确定为一种有效且安全的焦虑疗法 通常在年轻人发展的疾病中，其在与ASD的合并病例中的效用仍然未知。迄今为止， 没有研究在实验上将标准实践CBT与具有认知行为的干预进行了比较 是针对焦虑和ASD合并表现的儿童的个性化的。]文学中的这一差距是 特别关心 合并焦虑和现有的药理干预措施可能有一些缺点（例如，有限 该人群的功效，副作用以及药物X药物相互作用的潜力）。 [因此，我们是 提出一项随机对照试验将在三个治疗部位进行，以评估 个性化的CBT焦虑症（自闭症儿童焦虑的行为干预：BIACA） 相对于焦虑的标准实践CBT（应对CAT计划）。在过去的五年中，提议 BIACA干预已适应并根据高功能儿童的特征和需求进行调整和量身定制 与ASD；应对猫计划反映了经验支持的社区标准 多次由NIH资助的试验。]响应NIH路线图计划，BIACA采用了模块化处理 方法，使干预措施可以个性化每个年轻人的独特需求。 [因此，提议 研究将：（1）检查BIACA相对于应对CAT的功效，这代表了标准实践 治疗，（2）评估治疗收益的维持，（3）检查个性化的影响 干预功能结果，例如社会响应能力，孤独和友谊质量，（4）测试 自闭症的严重程度是治疗结果的主持人，（5）探索其他主持人和调解人 治疗结果。 分配给两个治疗条件之一。这项研究的三个招聘站点是UCLA， 南佛罗里达大学（USF）和Temple University。 USF将提供数据管理服务。 考虑到被诊断为ASD的儿童数量增加，以及 合并的焦虑，拟议的工作是针对ASD青年的独特需求量身定制的，将及时提供 对公共卫生工作的贡献。