Frontal function in Adolescent Cannabis Use Disorders

青少年大麻使用障碍的额叶功能

• 批准号: 7057641
• 负责人: Michael Damingo De Bellis
• 金额: $ 35.72万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-25 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057641
• 关键词: adolescence (12-20); behavioral /social science research tag; brain morphology; child mental disorders; clinical research; comorbidity; decision making; developmental neurobiology; executive function; functional magnetic resonance imaging; hippocampus; longitudinal human study; marijuana abuse; memory; morphometry; neuropsychological tests; neuropsychology; prefrontal lobe /cortex; reinforcer; white matter

DESCRIPTION (provided by applicant): In response to RFA-DA-05-007, we propose a 5-year cross sectional investigation with a one-year prospective follow-up to further our understanding of the neurobiological consequences of an adolescent onset cannabis use disorders (CUD; defined as DSM-IV cannabis dependence or abuse) on adolescent prefrontal and hippocampal structural and functional development. We propose to measure prefrontal and hippocampal cognitive function with a comprehensive neuropsychological battery and a functional MRI (fMRI) scan aimed at measuring subdivisions of prefrontal cortex (RFC) involved in decision-making and reward. We hypothesize that adolescent CUD will be associated with deficits of prefrontal and hippocampal function. Three adolescent groups will be compared: 1) adolescents with CUD, who do not have other comorbid substance use disorders (SUDs) and who are entering intensive substance treatment, 2) a high risk for SUD group of adolescents with mental disorders who do not have any SUDs and are age, sex, and sociodemographically matched to the CUD subjects, and 3) age, sex, and sociodemographically matched healthy community control adolescents. Specific aims are to compare measures of prefrontal and hippocampal structure and function in adolescents with CUD at baseline and prefrontal and hippocampal neuropsychological function at baseline, and 6 and 12 month follow-ups. At baseline, a well characterized subsample will undergo a novel fMRI task to measure RFC activity. We will explore the relationship between baseline measures of RFC activity in all adolescent groups to examine factors associated with: 1) nonremission or progression to other SUDs in the adolescent CUD group; and 2) emergence of an adolescent onset CUD in the high risk and healthy control groups; at 6 and 12 months. We will explore clinical summary variable measures of the subject's remission of cannabis use (age of onset of remission, duration of remission) and presence of mental health co-morbidity to try to identify the best clinical predictors of neuropsychological function (e.g. improvement) at 6 and 12 months. The adolescent brain is more vulnerable to the effects of drug abuse than the adult brain. This proposal has public health significance because we will comprehensively evaluate the effects of marijuana on adolescent brain and cognitive development, an understudied area.

描述（由申请人提供）： 为了响应RFA-DA-05-007，我们提出了为期5年的横截面调查，并进行了一年的预期后续调查，以进一步了解我们对青少年大麻使用障碍的神经生物学后果（CUD；定义为DSM-IV大麻依赖性或滥用）对青少年前春季前和Hippoctal and HippoCocpocapal and Hippocappal and Huppocampal结构和功能的发展。我们建议通过全面的神经心理电池和功能性MRI（fMRI）扫描来衡量前额叶和海马认知功能，旨在测量涉及决策和奖励的前额叶皮层（RFC）的细分。我们假设青少年CUD将与前额叶和海马功能的缺陷有关。 Three adolescent groups will be compared: 1) adolescents with CUD, who do not have other comorbid substance use disorders (SUDs) and who are entering intensive substance treatment, 2) a high risk for SUD group of adolescents with mental disorders who do not have any SUDs and are age, sex, and sociodemographically matched to the CUD subjects, and 3) age, sex, and sociodemographically matched healthy community control青少年。具体目的是比较基线时CUD的前额叶和海马结构的度量以及基线前额外和海马神经心理学功能的量度，以及6个月和12个月的随访。在基线时，特征良好的子样本将执行新的功能磁共振成像任务以测量RFC活动。我们将探讨所有青少年组中RFC活性的基线测量之间的关系，以检查与以下因素相关的因素：1）青少年CUD组的非排放或进展到其他SUD； 2）在高风险和健康对照组中出现青少年发作；在6和12个月。我们将探讨受试者缓解大麻使用的缓解（缓解年龄，缓解持续时间）的临床摘要变量措施和精神健康合并症的存在，以试图在6和12个月中确定神经心理学功能（例如改善）的最佳临床预测指标。与成人大脑相比，青少年大脑更容易受到药物滥用的影响。该提案具有公共卫生的意义，因为我们将全面评估大麻对青少年大脑和认知发展的影响，这是一个研究的领域。