New CVD risk factors for lowered congitive functioning

导致认知功能降低的新 CVD 危险因素

基本信息

批准号：
6861118
负责人：
MERRILL F ELIAS
金额：
$ 45.07万
依托单位：
UNIVERSITY OF MAINE ORONO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-04-01 至 2007-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6861118
关键词：
apolipoprotein E behavioral /social science research tag blood chemistry cardiovascular disorder epidemiology clinical research cognition disease /disorder proneness /risk gene environment interaction homocysteine human data human subject hypertension psychological tests tobacco abuse

项目摘要

DESCRIPTION: Arterial hypertension and high blood pressure (BP) are major risk factors for cardiovascular disease (CVD) and stroke; they are also risk factors for lowered cognitive functioning. Except for diabetes, there have been comparatively few studies of other common risk factors, particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability. This study is concerned with associations between cognitive functioning and three major CVD risk factors: (1) BP, (2) high total plasma homocysteine (tHcy), and (3) ApoE e4 genotype. Although high BP is a well-established risk factor for lowered cognitive functioning, tHcy and ApoE e4 are relatively unexplored variables with respect to cognitive functioning. A major objective is to investigate the individual, cumulative, and synergistic effects of BP, tHcy levels, and ApoE e4 genotype on cognitive functioning over a broad range of cognitive abilities. Three secondary, but important, objectives are to determine: (1) the extent to which the adverse influence of these three CYD risk factors on cognitive functioning is affected by the presence of coexisting CVD risk factors (e.g., cigarette smoking); (2) the cumulative impact of multiple risk factors on cognitive functioning; (3) the extent to which age effects on cognitive functioning are attenuated by adjustment for BP, tHey, ApoE genotype, and other CVD risk factors. The study makes use of existing data from a large longitudinal study of hypertension and cognitive functioning. Additionally, important new information about relations among tHey, ApoE, and BP will be obtained by calling back the longitudinal subjects for additional studies of cognitive functioning and making use of concurrent, prospective, and retrospective analyses.

描述：动脉高血压和高血压 (BP) 是主要风险心血管疾病（CVD）和中风的因素；它们也是危险因素用于降低认知功能。除了糖尿病以外，还有对其他常见危险因素的研究相对较少，特别是考虑可能产生不利影响的风险因素之间的相互关系认知能力。这项研究关注的是认知之间的关联功能和三个主要 CVD 危险因素：(1) 血压，(2) 高血浆总量同型半胱氨酸 (tHcy) 和 (3) ApoE e4 基因型。虽然高血压是认知功能、tHcy 和 ApoE 降低的明确危险因素 e4 是相对于认知功能而言尚未探索的变量。一个主要目标是研究个体、累积和协同作用血压、tHcy 水平和 ApoE e4 基因型对认知功能的影响广泛的认知能力。三个次要但重要的，目标是确定： (1) 不利影响的程度这三个 CYD 危险因素对认知功能的影响存在并存的 CVD 危险因素（例如吸烟）；（2）多种风险因素对认知功能的累积影响； (3) 的年龄对认知功能的影响在多大程度上被减弱调整血压、tHey、ApoE 基因型和其他 CVD 危险因素。该研究利用了一项大型纵向研究的现有数据高血压和认知功能。此外，重要的新信息通过回调可以得到关于 tHey、ApoE 和 BP 之间的关系认知功能和认知功能额外研究的纵向受试者利用同步、前瞻性和回顾性分析。

项目成果

期刊论文数量（39）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cardiovascular health and arterial stiffness: the Maine-Syracuse Longitudinal Study.

DOI：
10.1038/jhh.2013.131
发表时间：
2014-07
期刊：
Journal of human hypertension
影响因子：
2.7
作者：
通讯作者：

Parameters of Left Ventricular Mass and Dementia: Moving the Literature Forward.

左心室质量参数和痴呆：推动文献向前发展。

DOI：
10.1161/hypertensionaha.117.10371
发表时间：
2018
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
0
作者：
Elias,MerrillF;Torres,RachaelV;Davey,Adam
通讯作者：
Davey,Adam

Relation of Habitual Chocolate Consumption to Arterial Stiffness in a Community-Based Sample: Preliminary Findings.

基于社区的样本中习惯性巧克力消费与动脉僵硬的关系：初步发现。

DOI：
10.1159/000445876
发表时间：
2016
期刊：
Pulse (Basel, Switzerland)
影响因子：
0
作者：
Crichton,GeorginaE;Elias,MerrillF;Alkerwi,Ala'a;Stranges,Saverio;Abhayaratna,WalterP
通讯作者：
Abhayaratna,WalterP

Higher yogurt intake is associated with lower blood pressure in hypertensive individuals: Cross-sectional findings from the Maine-Syracuse Longitudinal study.

高血压患者较高的酸奶摄入量与较低的血压有关：缅因州-锡拉丘兹纵向研究的横断面研究结果。