Supramolecular mineralizing materials for dental tissue regeneration

用于牙组织再生的超分子矿化材料

• 批准号: 2534896
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2025
• 资助国家: 英国
• 起止时间: 2025 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2534896
• 关键词: Supramolecular; mineralizing; materials; dental; tissue

Material platforms based on supramolecular control of organic-inorganic interactions offer enormous potential to develop materials that can recreate the structural and functional properties of tissues such as bone and enamel. There is currently an unmet need to develop mineralizing materials that can recreate the properties of dental enamel. Loss of enamel can have profound impact on quality of life and result in invasive and costly interventions to prevent immense oral pain due to hypersensitivity, enamel erosion, or tooth decay. The project will be led by Prof. Alvaro Mata and Dr. Christabel Fowler and aims to develop a mineralizing material for the regenerating of dental tissues. The project will explore the use of protein-based matrixes to control organic-inorganic interactions, guide mineralization, and ultimately design and fabricate dental implants. The work will integrate supramolecular chemistry where there is a need to optimize protein matrixes, biomineralization where we aim to control apatite growth in clinical scenarios, and material processing where we look to enable fabrication of dental implants.

基于有机无机相互作用的超分子控制的材料平台为开发可以重现组织（例如骨骼和搪瓷）的结构和功能特性的材料提供了巨大的潜力。目前，需要开发可以重新创建牙齿牙釉质特性的矿化材料的需求。搪瓷的丧失可能会对生活质量产生深远的影响，并导致侵入性和昂贵的干预措施，以防止因超敏反应，搪瓷侵蚀或蛀牙而导致的口腔疼痛。该项目将由Alvaro Mata教授和Christabel Fowler博士领导，旨在开发一种矿化材料来再生牙科组织。该项目将探索基于蛋白质的基质来控制有机无机相互作用，引导矿化，并最终设计和制造牙科植入物。这项工作将整合超分子化学，需要优化蛋白质基质，生物矿化，我们旨在在临床情况下控制磷灰石的生长以及我们希望在其中制造牙科植入物的材料加工。