Metal-, Catalyst-, Light- and Electrolysis-Free Decarboxylative Radical Reactions - Towards a More Sustainable Future

无金属、无催化剂、无光和无电解的脱羧自由基反应 - 迈向更可持续的未来

• 批准号: 2518255
• 金额: --
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2518255
• 关键词: Metal; Catalyst; Light; Electrolysis; Free

This PhD project builds on surprising observations in our laboratories that, contrary to the accepted convention, mild, decarboxylative C-H functionalisation of heterocycles do not require metal, photocatalyst, light, high temperatures nor electrolysis to proceed well. A simple switch of solvent, followed by optimisation, successfully renders the C-H functionalisation of heterocycles metal-, catalyst-, light- and electrolysis-free (MCLE-free). Following these exciting preliminary results, we aim to convince the chemical community that we do not need to continue using toxic/precious/non-sustainable metals and catalysts or wasting precious energy to irradiate/heat/electrolyse these oxidative reactions just because it is the status quo. To achieve this, the aims of the project are to i) develop and showcase a myriad of useful MCLE free decarboxylative-functionalisation reactions which are sustainable, practical, cost-effective, scalable and suitable for late-stage functionalisation, ii) pursue further improvements on sustainability, and iii) showcase, using a case study, its utility for a diverse range of fields.

这个博士学位项目基于我们实验室中令人惊讶的观察结果，与公认的公约相反，杂环的轻度脱羧C-H功能化不需要金属，光催化剂，光，高温或电解能够很好地进行。溶剂的简单开关，然后进行优化，成功地呈现了杂环金属，催化剂，轻质和无电解的C-H功能化（无MCLE）。遵循这些令人兴奋的初步结果，我们的目标是说服化学界，我们不需要继续使用有毒/珍贵/不可持续的金属和催化剂，或者浪费宝贵的能量来照射/热/电解这些氧化反应，只是因为它是现状。为了实现这一目标，该项目的目的是i）开发和展示无数有用的MCLE免费脱羧作用反应，这些反应可持续，实用，实用，具有成本效益，可扩展性且适合于晚期功能，ii）ii）追求可持续性的进一步改进，以及iii）在案例中展示，使用一个案例研究，该案例为各种领域提供了案例研究。