MRI and MRS Markers of Epileptogenesis

癫痫发生的 MRI 和 MRS 标志物

• 批准号: 6967436
• 负责人: Fred Alexander Lado
• 金额: $ 20.19万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6967436
• 关键词: amygdala; aspartate; bioimaging /biomedical imaging; biomarker; brain disorder diagnosis; brain injury; brain mapping; creatine; developmental neurobiology; entorhinal cortex; epilepsy; generalized seizures; hippocampus; immature animal; laboratory rat; lateral olfactory area; magnetic resonance imaging; neuroimaging; neuropathology; nuclear magnetic resonance spectroscopy; pathologic process; prognosis; somesthetic sensory cortex; thalamus

DESCRIPTION (provided by applicant): Epilepsy is a common disease, affecting approximately 0.5% of the US population, and disproportionately affecting children. Often, seizures develop months or years - the 'latent period' - following an initial brain injury, such as an episode of SE in early childhood. Not all individuals with comparable early life SE, however, develop epilepsy. Indeed, only a minority of children at risk subsequently develops epilepsy. To prospectively select children most likely to benefit from antiepileptogenic therapy it is necessary to identify surrogate markers. The recent advances in neuroimaging suggest that it may be possible to use neuroimaging tools to identify these surrogate markers. Identification of surrogate markers and would make it possible to initiate antiepileptogenic therapies only in children at risk. Furthermore, since it may take years before seizures develop following an injury, the identification of neuroimaging markers predicting epilepsy can accelerate the discovery of appropriate age-specific treatments to prevent epilepsy Thus, additional surrogate markers must be identified. To be of greatest use, markers either should persist through the latent period or should appear at distinct times within the latent period. It is also desirable that these markers provide insight into the evolution of the biological processes that culminate in epilepsy. To circumvent the problem of long latent periods in the development of human epilepsy, we propose to identify surrogate markers of epileptogenesis in lithium-pilocarpine immature rat model of epilepsy where seizures develop on average ten weeks after status epilepticus. By prospectively studying rats using magnetic resonance imaging and spectroscopy methods, we propose to identify brain changes that precede and predict the development of epilepsy.

描述（由申请人提供）：癫痫是一种常见疾病，影响了约0.5％的美国人口，并且对儿童产生了不成比例的影响。通常，癫痫发作发生了几个月或数年 - “潜在时期” - 最初的脑损伤，例如童年时期的SE发作。但是，并非所有具有可比早期生活的人都会发展出癫痫。确实，只有少数有危险的儿童随后发展癫痫病。为了预期选择最有可能受益于抗癫痫疗法的儿童，有必要识别替代标志物。神经影像学的最新进展表明，可以使用神经影像学工具来识别这些替代标记。鉴定替代标记物，将有可能仅在有风险的儿童中开始抗癫痫疗法。此外，由于可能需要几年的时间才能在受伤后发育，因此预测癫痫病的神经影像学标记物可以加速发现适当的年龄特异性治疗以防止癫痫病，因此必须识别出额外的替代标记。最有用的用途是，标记要么应该在潜在时期内持续存在，要么应该在潜在时期内出现在不同的时间。还希望这些标记能够洞悉最终在癫痫中的生物学过程的演变。 为了解决人类癫痫发育中长期潜在时期的问题，我们建议在癫痫的癫痫锂中未成熟大鼠模型中鉴定癫痫发生的替代标志物，在该模型中，癫痫发作平均在癫痫病后十周出现。通过使用磁共振成像和光谱法的前瞻性研究大鼠，我们建议识别先前的大脑变化并预测癫痫的发展。