Screening for Barrett's in Otolaryngology Patients

耳鼻喉科患者的巴雷特氏病筛查

• 批准号: 6846552
• 负责人: BLAIR Anderson JOBE
• 金额: $ 13.31万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6846552
• 关键词: Barretts esophagus; bioimaging /biomedical imaging; cancer risk; clinical research; diagnosis quality /standard; endoscopy; gastrointestinal imaging /visualization; human subject; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; patient oriented research; reflux esophagitis

DESCRIPTION (provided by applicant): This application proposes a training program to develop Blair A. Jobe, MD into an independent clinician-scientist specializing in investigations of Barrett's esophagus and esophageal cancer. Dr. Jobe is a board certified General Surgeon with subspecialty training in laparoscopic and esophageal surgery. The mentored career development plan consists of a three-tiered approach: a didactic education resulting in a Masters in Clinical Investigation degree, a broad-based experiential learning program, and a mentored clinical research experience. The primary goal of this program will be for Dr. Jobe to achieve independence as a clinical investigator in all respects. Dr. Jobe is currently enrolled in the Human Investigations Program at Oregon Health and Science University (OHSU). This is a two year K30 (NIH) sponsored program for the purposes of developing patient-oriented research skills. Mentored research will be conducted under the direction of a mentorship committee composed of Dr. Cynthia Morris, Professor of Medical Informatics and Outcomes Research, OHSU, Dr. David Lieberman, Chief, Division of Gastroenterology, OHSU, and Dr. John Hunter, Chairman, Department of Surgery, OHSU. Dr. Jeffrey Peters from the University of Southern California will serve as an off-site mentor and committee member. The proposed research focuses on improving risk stratification for esophageal adenocarcinoma. The fact that most patients are unaware of the presence of Barrett's esophagus prior to cancer diagnosis and because a large proportion of these patients never develop heartburn or reflux, suggests that the current GERD symptom-based screening paradigm may be inadequate. We theorize that patients with extraesophageal reflux symptoms are at risk for unrecognized esophageal injury and thus Barrett's esophagus. We hypothesize that endoscopic screening of patients with extraesophageal reflux symptoms will reveal a significantly higher prevalence of Barrett's esophagus when compared to patients without symptoms of gastroesophageal reflux. The primary aim is to establish that patients with extraesophageal reflux symptoms who are referred to an otolaryngology clinic have a prevalence of Barrett's metaplasia equivalent to that of a population with GERD symptoms. A secondary aim is to establish that in-office unsedated small-caliber endoscopy is accurate and acceptable to patients when employed within a screening program for Barrett's esophagus.

描述（由申请人提供）： 该申请提出了一项培训计划，以开发医学博士Blair A. Jobe，成为一个独立的临床医生 - 科学家，专门研究Barrett的食管和食管癌。 Jobe博士是一名经过董事会认证的普通外科医生，并在腹腔镜和食管手术中接受了专科培训。指导的职业发展计划包括一种三层方法：一种教育教育，导致临床研究硕士学位，基于广泛的体验学习计划以及受过指导的临床研究经验。该计划的主要目标是让乔布博士在各个方面成为临床研究者的独立性。 Jobe博士目前正在俄勒冈州健康与科学大学（OHSU）的人类调查计划。这是为期两年的K30（NIH）赞助计划，目的是发展面向患者的研究技能。指导研究将在由OHSU医学信息学和成果研究教授Cynthia Morris博士组成的指导下进行，OHSU，OHSU胃肠病学部长David Lieberman博士和OHSU外科外科院长John Hunter博士。南加州大学的Jeffrey Peters博士将担任异地导师和委员会成员。拟议的研究重点是改善食道腺癌的风险分层。大多数患者在癌症诊断之前没有意识到巴雷特食管的存在，并且由于这些患者中有很大一部分从未出现胃灼热或反流，这表明当前基于GERD症状的筛查范式可能不足。我们认为，患者外室反流症状的患者有未识别的食管损伤的风险，因此有巴雷特的食管。我们假设与没有胃食管反流症状的患者相比，与没有胃食管症状的患者相比，对食管外反流症状的患者的内窥镜检查将显示出明显更高的患病率。主要目的是确定被称为耳鼻喉科诊所的吞噬外反流症状的患者的患病率与Barrett的Metaplasia相当于患有GERD症状的人群。第二个目的是确定在筛查Barrett食管筛查计划中，患者在办公室内未经修剪的小型内窥镜检查是准确且可接受的。