OCT Probe for Dysplastic Mucosa in Barrett's Esophagus

Barrett 食管发育不良粘膜 OCT 探头

• 批准号: 6816885
• 负责人: ZHILIN HU
• 金额: $ 7.55万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6816885
• 关键词: Barretts esophagus; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; cancer risk; clinical biomedical equipment; clinical research; clinical trials; computer program /software; computer system design /evaluation; diagnosis design /evaluation; diagnosis quality /standard; endoscopy; gastric mucosa; gastrointestinal disorder diagnosis; gastrointestinal epithelium; gastrointestinal imaging /visualization; human middle age (35-64); human old age (65+); human subject; hyperplasia; neoplasm /cancer diagnosis; optical tomography; patient oriented research; preneoplastic state; three dimensional imaging /topography

DESCRIPTION (provided by applicant): This proposal is to design, build, and test a screening optical coherence tomography (OCT) catheter probe with a centering balloon. The probe will be compatible with the endoscopic OCT (EOCT) imaging system that was developed in the Endoscopic Research Laboratory (ERL) at University Hospitals of Cleveland (UHC). This EOCT system was designed to detect dysplastic (precancerous) change in conditions that predispose the development of cancer (e.g. Barrett's esophagus). With this new probe, the EOCT system will become suitable for surveillance examination of a large surface area of tissue, which in a patient with well-developed Barrett's esophagus can be as much as 20 cm^2. Surveillance is not possible with the current probe as this images only a small volume of tissue. The new probe will have a diameter slightly larger than the current 2.4 mm catheter probe, but it will be easy inserted through the 3.7 mm accessory channel of endoscopes currently in use. The lateral resolution, optimized by optical design is expected to be 26 micrometers. The probe with balloon will be inserted through the endoscope and positioned in the esophagus below the segment of interest. The balloon will be expanded to center the probe in the lumen of the esophagus and to support the lumen to a diameter of 22 mm. The optical elements will protrude beyond the balloon so that the probe will image the entire circumference of the lumen while avoiding imaging tissue compressed by the balloon. To create a digital image of the entire length of the segment of interest, the probe with balloon will be withdrawn proximally toward the patient's mouth by a specially designed pull back device at a constant speed. In this fashion, a 3-dimensional OCT image is obtained of the segment of esophagus that has transformed to the precancerous Barrett's epithelium. To demonstrate the feasibility, safety and potential efficacy of the new EOCT catheter probe with centering balloon, a small scale clinical trial will be conducted in 10 to 20 patients with Barrett's esophagus who undergo regular endoscopic surveillance.

描述（由申请人提供）： 该建议是设计，构建和测试带有居中气球的筛选光学相干断层扫描（OCT）导管探测器。该探针将与克利夫兰大学医院（UHC）的内窥镜研究实验室（ERL）开发的内窥镜OCT（EOCT）成像系统兼容。该EOCT系统旨在检测易于癌症发展的疾病的发育异常（癌前）变化（例如，巴雷特的食管）。通过这种新的探针，EOCT系统将适合对大型组织的监视检查，在患有发达的Barrett食管的患者中，该组织可以多达20 cm^2。目前的探针无法进行监视，因为此图像仅图像一小部分组织。新探针的直径将比当前的2.4毫米导管探针略大，但是可以轻松地通过当前正在使用的内镜的3.7 mm附件通道插入。通过光学设计优化的横向分辨率预计为26微米。带有球囊的探针将通过内窥镜插入，并位于感兴趣段以下的食道。气球将扩展，以将探针置于食道的腔内，并将管腔支撑至直径22毫米。光学元件将伸出气球超出气球，以便探测会对管腔的整个周长进行成像，同时避免成像组织被气球压缩。为了创建感兴趣段的整个长度的数字图像，带有球囊的探测器将以恒定的速度靠近患者的嘴靠近患者的嘴巴撤回。以这种方式，获得了三维的OCT图像，该图像已转化为癌前Barrett上皮的食道片段。为了证明新的EOCT导管探测器具有居中气囊的可行性，安全性和潜在疗效，将在10至20名Barrett的食管患者中进行小型临床试验，他们接受了定期的内窥镜监测。