Detection/Dysplastic Epithelium/Gastrointestinal Tract

检测/发育不良上皮/胃肠道

基本信息

批准号：
6793254
负责人：
MICHAEL V SIVAK
金额：
$ 49.74万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2006-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Dysplasia is the precursor of cancer in a number of gastrointestinal (GI) disorders. Dysplasia is fundamentally a microscopic diagnosis based on specific changes in cells and architecture of the mucosa. A key problem is that dysplastic mucosa is usually not detectable by standard GI endoscopy, a major technical limitation that prevents detection of pre-malignant lesions when therapeutic intervention would be optimal and even curative. Recent studies by us and others have led to the development of new endoscopic approaches that provide an unprecedented quality and accuracy of images of the GI mucosa. This application is focused on the utilization of endoscopic optical coherence tomography (EOCT), a light based imaging modality that generates cross-sectional representations of biological tissues, with a resolution at least ten times greater than that achievable with any of the existing endoscopic imaging modalities. This extremely promising new imaging system is still in its early stages, and intense study is required to solve some of the technological restrictions still existing, such as the small size of the scanning area, imprecise control of the image stream required for microscopic diagnosis, uncertain targeting of the biopsy site, and distortion of the tissue under examination. Based on our preliminary ex vivo and in vivo results, and the integrated efforts of the multidisciplinary team of experts we have assembled, we feel confident that the above limitations can be properly addressed and solved. Thus, the overall goal is to adapt EOCT to the detection of dysplasia in the GI tract and determine its accuracy in the detection of dysplasia in common human pre-malignant conditions. This will be accomplished through the following specific aims: 1) To evaluate prospectively the yield and accuracy of EOCT in endoscopic surveillance of dysplasia in Barrett's esophagus; 2) To use EOCT imaging to measure the density of aberrant colonic crypt foci; and 3) To develop an EOCT probe for imaging pancreatic ductal epithelium, demonstrate the feasibility of pancreatic EOCT, and correlate EOCT images with histological changes of dysplastic ductal epithelium. Achievement of these aims will significantly improve the capacity to detect pre-malignant or early malignant lesions in the GI tract and allow early therapeutic interventions that will positively impact on patient care and survival.

描述（由申请人提供）：发育不良是许多胃肠道（GI）的癌症的前体疾病。从根本上，发育不良是基于微观诊断粘膜细胞和结构的特定变化。一个关键问题是通常无法通过标准GI内窥镜检查检测到发育不良的粘膜主要技术限制，以防止检测到恶性病变当治疗干预是最佳甚至治疗时。最近的我们和其他人的研究导致了新内窥镜的发展提供了前所未有的质量和准确性的方法胃肠道。该应用程序的重点是内窥镜的利用光学相干断层扫描（EOCT），一种基于轻的成像方式生成生物组织的横截面表示分辨率至少比任何一项都可以实现的分辨率大十倍现有的内窥镜成像方式。这种非常有前途的新成像系统仍处于早期阶段，需要进行深入的研究来解决一些技术限制仍然存在，例如小规模在扫描区域，对图像流的不精确控制所需的图像流微观诊断，活检部位的不确定靶向和失真正在检查的组织。基于我们的初步体内和体内结果以及多学科专家团队的综合努力我们已经组装了，我们有信心上述限制可以是正确解决和解决。因此，总体目标是使EOCT适应检测胃肠道的发育不良并确定其准确性在人类普通前的恶性疾病中检测发育不良。这将是通过以下特定目的完成：1） EOCT在发育不良的内窥镜监测中的产量和准确性巴雷特的食道； 2）使用EOCT成像来测量异常的密度结肠隐窝灶； 3）开发用于成像胰腺成像的EOCT探针导管上皮，证明了胰腺EOCT的可行性，并且将EOCT图像与生育性导管的组织学变化相关上皮。这些目标的实现将显着提高能力检测胃肠道中的恶性或早期恶性病变，并允许早期的治疗干预措施将对患者护理产生积极影响和生存。

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Carotid lesions in outpatients with nonalcoholic fatty liver disease.

非酒精性脂肪肝门诊患者的颈动脉病变。

DOI：
10.3748/wjg.15.4770
发表时间：
2009
期刊：
World journal of gastroenterology
影响因子：
4.3
作者：
Ramilli,Stefano;Pretolani,Stefano;Muscari,Antonio;Pacelli,Barbara;Arienti,Vincenzo
通讯作者：
Arienti,Vincenzo

WJG sets an example of internationalization for other Chinese academic journals.

《WJG》为其他中国学术期刊国际化树立了典范。

DOI：
10.3748/wjg.v16.i22.2707
发表时间：
2010
期刊：
World journal of gastroenterology
影响因子：
4.3
作者：
Zu,Guang-An
通讯作者：
Zu,Guang-An

Trainee fatigue: are new limits on work hours enough?

实习生疲劳：新的工作时间限制是否足够？

DOI：
10.1503/cmaj.1031613
发表时间：
2004
期刊：
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
影响因子：
0
作者：
Howard,StevenK;Gaba,DavidM
通讯作者：
Gaba,DavidM

Assessment of the effectiveness of the peptide inhibitor homologous to the transforming growth factor β cytokine blocking the TGFβRI/TGFβRII receptor complex-pilot study.