Exploring the Skin Microbiome's response to UV light and investigating whether this response alters in the presence of UV filters

探索皮肤微生物群对紫外线的反应，并研究这种反应在紫外线过滤器存在的情况下是否会改变

• 批准号: 2493978
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2493978
• 关键词: Exploring; Skin; Microbiome; response; UV

UV light has a substantial effect on our skin which has been characterised well and documented throughout literature. Most of the available data in this area focusses on the damaging effects of UV light on the epidermis and dermis of the skin. Generally, in skin care research the focus has always been on these traditional skin layers; the epidermis, dermis and hypodermis. However, over the past few years there has been a new area of interest which has gained significant attention in the personal care industry; the skin microbiome. The skin microbiome is the diverse microbial ecosystem on our skin surface and therefore the microorganisms that reside in this environment are the very first to come in to contact with UV light when striking the skin. It is therefore of utmost importance to understand how UV light impacts these microbes whether beneficially, adversely or neutrally. There is a continual increase in evidence to highlight the importance of a healthy microbiome in order to have healthy skin therefore understanding the impact of UV on this ecosystem and how we can provide and implement protection mechanisms is of substantial interest. The aim of this project is therefore to firstly understand the impact of UV light (UVA and UVB) and potentially infra-red and visible light on the skin microbiome. The second aim is to investigate if and how UV filters (both inorganic and organic filters) can alter the effects of UV light on the skin microbiome. Questions to be answered within this second aim include but are not limited to the following;- Do inorganic and organic filters show any protective effects for the skin microbiome against UVA and/or UVB light?- Do these filters selectively protect some microorganisms and not others within the microbial community? Are these commensal or pathogenic microorganisms?- Do these filters lead to a change in the skin microbiome balance i.e. is there an increase/decrease/impartial effect in microbial diversity or microbial density?- In the absence of UV light, do these inorganic and organic filters have a beneficial, adverse or neutral effect on the skin microbiome i.e. regardless of any beneficial effect they may have in microbial UV protection, do the chemistries themselves harm or benefit the skin microbiome?- Does IR light influence the skin microbiome, and if so, are IR filters able to protect against these effects on the microorganisms?This research would significantly contribute towards enhancing our understanding in sun care protection as research to date has been focussed on UV effects on the traditional skin layers. This focus on UV effects on the skin microbiome will allow us to understand and therefore develop suitable sun care products to protect this significant ecosystem which has been shown to be integral to our skin health.. The project sits well within the DTP theme of World class underpinning biosciences as it will firther our understanding of how everyday products like sunscreens interact with the skins microbiome. To date no data is available in this area. The study is also aligned with the BBSRC's strategic research priority 'Bioscience for health' and ' integrative microbiome research' and it will improve our understanding of sunscreens on our microbiome.

紫外线对我们的皮肤具有重大影响，该皮肤的表征很好，并在整个文献中都有文献作用。该区域中的大多数可用数据都集中在紫外线对皮肤表皮和真皮的破坏作用。通常，在皮肤护理研究中，重点一直放在这些传统的皮肤层上。表皮，真皮和皮下注射。但是，在过去的几年中，人们有一个新的兴趣领域在个人护理行业中引起了重大关注。皮肤微生物组。皮肤微生物组是我们皮肤表面上的多种微生物生态系统，因此，在这种环境中存在的微生物是撞击皮肤时首先接触紫外光的微生物。因此，重要的是要了解紫外线如何影响这些微生物，无论是对有益，不利还是中立。证据不断增加，以强调健康微生物组的重要性，以使皮肤健康，因此了解紫外线对该生态系统的影响以及我们如何提供和实施保护机制具有很大的兴趣。因此，该项目的目的是首先了解紫外线（UVA和UVB）的影响，以及对皮肤微生物组的潜在红外和可见光。第二个目的是研究紫外线过滤器（无机和有机过滤器）是否以及如何改变紫外线对皮肤微生物组的影响。在第二个目标中要回答的问题包括但不限于以下内容； - 无机和有机过滤器是否对皮肤微生物组对UVA和/或UVB光显示任何保护作用？ - 这些过滤器是否有选择地保护某些微生物，而不是微生物社区中的其他微生物？这些均质或致病性微生物是否是否会导致皮肤微生物组平衡发生变化，即在微生物多样性或微生物密度中会增加/减少/公正效应吗？ - 在没有紫外线的情况下，这些无机和有机过滤器对皮肤微生物的效果是否有益于紫外线，对这些无机和有机过滤的作用是否有益。紫外线保护，化学物质本身是否损害或使皮肤微生物组受益？ - 红外光线是否会影响皮肤微生物组，如果是这样，IR滤光片是否能够防止对微生物的影响？这项研究将极大地有助于增强我们对日晒保护的理解，因为迄今为止，研究对传统的皮肤层面的研究对紫外线的影响都对我们的传统皮肤层面作用。对紫外线对皮肤微生物组的影响的重点将使我们能够理解并开发合适的防晒产品，以保护这一重要的生态系统，该生态系统已被证明是我们皮肤健康不可或缺的。该项目很好地位于世界一流的DTP主题中，基于世界一流的生物科学的主题，因为它将对我们如何与Sunscreens（例如Sunscreens）与皮肤微生物相互作用，这将使我们对如何与Sunscreens相互作用。迄今为止，该区域没有可用的数据。该研究还与BBSRC的战略研究优先级“健康生物科学”和“综合微生物组研究”保持一致，它将提高我们对微生物组防晒霜的理解。