BEAT OSTEOPOROSIS: NOURISH & EXERCISE SKELETONS (BONE)

战胜骨质疏松症：滋养

• 批准号: 6637007
• 负责人: CHRISTINA D ECONOMOS
• 金额: $ 52.96万
• 依托单位: TUFTS UNIVERSITY MEDFORD
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-04 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6637007
• 关键词: body composition; body physical activity; bone density; bone metabolism; calcium metabolism; child (0-11); clinical research; dietary calcium; disease /disorder prevention /control; focus groups; health behavior; human subject; human therapy evaluation; longitudinal human study; muscle strength; nutrition related tag; osteoporosis; outcomes research; parent offspring interaction

Osteoporosis affects more than 28 million Americans and accounts for more than 1.5 million fractures annually, at a cost of 513.8 billion. One of the most effective ways to prevent osteoporosis is to build a strong, dense skeleton during the growing years to act as a reserve in later life. Furthermore, changes in individual behaviors and lifestyle preferences in younger children may last through the critical adolescent period and continue into adulthood, providing a lifetime of optimal bone health. The primary aim of this study is to develop, implement and evaluate a multi-faceted intervention in after-school programs that will increase bone accretion and muscular strength in early elementary school children. The intervention will include weight loading physical activity and calcium-rich snacks for children as well as age- appropriate, behaviorally focused active learning to promote skill building and self-competence. It will also include a parent/caregiver communications module that by provides specific activities and practical information to complement and reinforce the direct intervention with the children. A mascot and logo will be used to foster positive attitudes about calcium-rich foods and physical activity; incentives and goal setting will be used to encourage sustained behavior. One thousand eight hundred first and second grade children from 60 after-school programs in up to 10 diverse communities throughout Massachusetts will be randomized and studied for 24 months. Matched program groups will receive either The BONES Project (n=24), The BONES Project plus a parent/caregiver component (n=12); or they will serve as controls (n=24). Follow-up will continue for 12 months after the intervention period. The primary outcomes will be bone quality and muscular strength. Secondary outcomes will include physical activity levels, calcium consumption, body composition, self-perception of physical abilities and appearance, and influencing factors toward relevant healthy lifestyle behaviors, such as knowledge and attitudes. The control group will receive a "delayed" intervention after termination of the 36-month study. Focus group research with after-school program leaders, parents/caregivers, and children prior to initiation will provide information to optimize the campaign design. Findings from this study will promote our understanding of health behaviors in young children and the effect of parental involvement on these behaviors. Implementation of the same intervention within this widely diverse set of communities will guide appropriate cultural, community and socioeconomic-specific modifications and permit easier replication of the program. Because the intervention utilizes the existing after-school framework large numbers of children can be reached. Results from this study will provide an appropriate model for national replication and sustainability of a program to beat osteoporosis by nourishing and exercising skeletons early in life.

骨质疏松症影响着超过 2800 万美国人，每年造成超过 150 万例骨折，造成 5138 亿美元的损失。预防骨质疏松症最有效的方法之一是在生长过程中建立坚固、致密的骨骼，为以后的生活做好储备。此外，年幼儿童的个人行为和生活方式偏好的变化可能会持续到关键的青春期并持续到成年期，从而提供终生最佳的骨骼健康。本研究的主要目的是制定、实施和评估课后计划的多方面干预措施，以增加早期小学生的骨质增生和肌肉力量。干预措施将包括为儿童提供负重体力活动和富含钙的零食，以及适合年龄的、以行为为重点的主动学习，以促进技能建设和自我能力。它还将包括一个家长/看护者沟通模块，通过提供具体活动和实用信息来补充和加强对儿童的直接干预。吉祥物和标志将用于培养对富含钙的食物和体育活动的积极态度；激励措施和目标设定将用于鼓励持续的行为。来自马萨诸塞州多达 10 个不同社区的 60 个课外项目的 1,800 名一年级和二年级儿童将被随机分组​​并进行为期 24 个月的研究。匹配的项目组将收到 BONES 项目 (n=24)、The BONES 项目加上家长/看护者部分 (n=12)；或者将它们作为对照（n=24）。干预期结束后，随访将持续 12 个月。主要结果是骨骼质量和肌肉力量。次要结果包括身体活动水平、钙消耗、身体成分、对身体能力和外表的自我认知，以及相关健康生活方式行为的影响因素，例如知识和态度。对照组将在为期36个月的研究结束后接受“延迟”干预。在开始之前与课外项目负责人、家长/看护者和儿童进行焦点小组研究，将为优化活动设计提供信息。这项研究的结果将促进我们对幼儿健康行为以及父母参与对这些行为的影响的理解。在这个广泛多样化的社区中实施相同的干预措施将指导适当的文化、社区和社会经济具体修改，并允许更容易地复制该计划。由于干预措施利用了现有的课外框架，因此可以惠及大量儿童。这项研究的结果将为通过在生命早期滋养和锻炼骨骼来战胜骨质疏松症的计划在全国范围内复制和可持续性提供适当的模型。

项目成果

Precision of Lunar Achilles+ bone quality measurements: time dependency and multiple machine use in field studies.

月球跟腱骨质量测量的精度：时间依赖性和现场研究中的多台机器使用。

• 发表时间: 2007-11
• 作者: Economos, C D;Sacheck, J M;Wacker, W;Shea, K;Naumova, E N
• 通讯作者: Naumova, E N

Beat osteoporosis - nourish and exercise skeletons (BONES): a group randomized controlled trial in children.

击败骨质疏松症 - 滋养和锻炼骨骼 (BONES)：一项针对儿童的分组随机对照试验。

• 发表时间: 2020
• 影响因子: 2.4
• 作者: Economos, Christina D;Hennessy, Erin;Chui, Kenneth;Dwyer, Johanna;Marcotte, Lori;Must, Aviva;Naumova, Elena N;Goldberg, Jeanne
• 通讯作者: Goldberg, Jeanne