ANTERIOR CINGULATE ACTIVATION IN GERIATRIC DEPRESSION

老年抑郁症中的前扣带回激活

• 批准号: 6959017
• 负责人: Faith M Gunning
• 金额: $ 16.09万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6959017
• 关键词: brain mapping; cingulate gyrus; clinical research; cognition; emotions; human old age (65+); human subject; major depression; neuropsychological tests; neuropsychology; pathologic process; patient oriented research; psychological aspect of aging; psychopathology

DESCRIPTION (provided by applicant): This proposal is for a K23 Patient-Oriented Mentored Scientist Award. The applicant is a clinical neuropsychologist with research training and publications on structural and functional MRI correlates of aging. The goal of the proposal is to support the applicant's growth into an independent investigator, whose research focuses on the neurobiology of geriatric depression, using cognitive and affective neuroscience approaches. Neuropsychological, electrophysiology, and structural MRI findings suggest that anterior cingulate (ACC) dysfunction contributes to the pathogenesis of late-life depression and some of these abnormalities even influence the response of depression to treatment. fMRI offers a more direct approach to investigate ACC dysfunction that may underlie cognitive and affective disturbance in late-life depression. The training and research proposed in this application aims to prepare the applicant to become an effective independent investigator in the neurobiology of late-late mood disorders. Coursework, seminars, tutorials, collaborative studies, and paper writing all were planned with the goal of giving the applicant substantive knowledge in the cognitive and affective neuroscience of depression, skills in fMRI task development and data analysis, and training in clinical trials methodology. The training environment (Weill Cornell Institute of Geriatric Psychiatry) is a Center with findings and a research agenda focused on the role of ACC in geriatric depression and thus would be fertile ground for the applicant's growth. Mentors and experts from Cornell, NIMH, Harvard, University of Pennsylvania, and NKI were selected with complementary expertise in areas relevant to the applicant's training needs. The training experience was designed in a way that the applicant has the opportunity to benefit maximally from interaction with her mentors. Moreover, the applicant will pursue a research project that can function as the training ground for accomplishing her educational aims. The project will use neurobehavioral probes to elicit activation of the ACC in geriatric depressed patients and age-matched comparison subjects. The project hypothesizes that 1) In both groups, cognitive interference conditions and negatively valenced word conditions will elicit differential activation of the ACC; 2) In response to cognitive and emotional probes, activation in the dorsal and perigenual ACC will distinguish geriatric depressed patients from comparison subjects.

描述（由申请人提供）：该提案是针对K23以患者为导向的科学家奖的。申请人是一名临床神经心理学家，研究了有关衰老的结构和功能性MRI相关性的研究培训和出版物。该提案的目的是使用认知和情感神经科学方法来支持申请人的成长为独立研究者，其研究重点介绍了老年抑郁症的神经生物学。神经心理学，电生理学和结构MRI发现表明，前扣带回（ACC）功能障碍有助于晚期抑郁症的发病机理，其中一些异常甚至会影响抑郁症对治疗的反应。 FMRI提供了一种更直接的方法来研究ACC功能障碍，这可能是晚期抑郁症的认知和情感障碍的基础。 本申请中提出的培训和研究旨在使申请人成为后期情绪障碍神经生物学的有效独立研究者。课程工作，研讨会，教程，协作研究和论文写作都是计划的，目的是为抑郁症的认知和情感神经科学，fMRI任务开发和数据分析的技能以及临床试验方法中的培训提供申请人的实质性知识。培训环境（威尔·康奈尔（Weill Cornell）老年精神病学研究所（Weill Cornell Institute of Geriaturic Psychiatry）是一个中心，其发现和研究议程的重点是ACC在老年抑郁症中的作用，因此将成为申请人成长的肥沃基础。在与申请人的培训需求有关的领域方面，选择了康奈尔，纽约，哈佛大学，宾夕法尼亚大学和NKI的导师和专家。培训经验的设计方式是申请人有机会从与导师的互动中最大程度地受益。此外，申请人将追求一个研究项目，该项目可以充当实现其教育目标的培训理由。该项目将使用神经行为探针在老年抑郁症患者和年龄匹配的比较主题中引起ACC的激活。该项目假设1）在两组中，认知干扰条件和否定价值的单词条件将引起ACC的差异激活； 2）响应认知和情绪探针，背侧和阴性ACC的激活将使老年抑郁症患者与比较受试者区分开。