Cortical Responses To Single & Multi-Site Skin Stimuli

皮质对单身的反应

• 批准号: 6889266
• 负责人: Mark A Tommerdahl
• 金额: $ 35.56万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6889266
• 关键词: Saimiri; brain electrical activity; perception; single cell analysis; skin; stimulus /response; touch

DESCRIPTION (provided by applicant): The primary goal of the experiments proposed in this application is to identify dimensions of SI cortical neuroelectrical activity that could account (i.e., serve as the SI correlate) for the perceptual experiences evoked by selected conditions of single- and multi-site skin stimulation. Every experiment will obtain measures of both the global and single neuron responses to each stimulus condition by using a novel and powerful combination of the methods of near-infrared optical intrinsic signal (OIS) imaging and extracellular recording of single neuron spike discharge activity. Two series of combined OIS imaging/neurophysiological recording experiments are proposed. In the first series (Series I), the global and single neuron responses evoked by single-site skin stimulation will be obtained for skin flutter stimuli that differ only in amplitude. Each experiment of this series will use the same range of amplitudes used in published human psychophysical studies of the effects of flutter amplitude on perceived intensity. The Series II experiments will evaluate the responses of SI to dual-site skin flutter stimulation - they will seek to identify SI correlates for well-established perceptual phenomena (e.g., spatial compression, intensity modulation, etc.) that human psychophysical studies have demonstrated under comparable conditions of multi-site skin stimulation. Collectively, the information obtained in the Series I and II experiments should enable quantification of stimulus-directed interactions between topographically and cytoarchitectonically distinct regions within SI cortex - interactions of considerable potential functional importance which although predicted on theoretical grounds, have not been addressed in any experimental study published to date.

描述（由申请人提供）：本申请中提出的实验的主要目标是确定可以说明（即用作SI相关性）的SI皮质神经电活动的维度，以通过单位和多站点皮肤刺激的单位和多站点皮肤刺激所唤起的感知体验。每个实验都将通过使用新颖且强大的组合来获得对每种刺激条件的全局和单个神经元反应的度量，这是近红外光学固有信号（OIS）成像的方法和单个神经峰放电活性的细胞外记录的方法。提出了两个系列的OIS成像/神经生理记录实验。在第一个系列（I系列）中，将获得仅在振幅上不同的皮肤颤动刺激中引起的全局和单个神经元反应。该系列的每个实验将使用与扑动振幅对感知强度的影响的人类心理物理研究中使用的幅度相同的幅度。 II系列实验将评估SI对双点皮肤扑动刺激的反应 - 他们将寻求鉴定SI相关性的相关性感知现象（例如，空间压缩，强度调节等），以表明人类心理物理研究在多层皮肤皮肤刺激的可比条件下证明了人类心理物理学研究。总的来说，在第I和II系实验中获得的信息应能够量化Si Cortex内的地形和细胞结构上不同区域之间的刺激指导的相互作用 - 在任何实验研究中都没有在任何实验研究中都解决了相当大的潜在功能重要性的相互作用。