IMAGING THE RESPONDING SI NEURONAL POPULATION

对响应 SI 神经元群进行成像

• 批准号: 2270480
• 负责人: Mark A Tommerdahl
• 金额: $ 12.46万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2270480
• 关键词: NMDA receptors; Saimiri; autoradiography; brain electrical activity; brain imaging /visualization /scanning; brain metabolism; cats; evoked potentials; infrared microscopy; sensory receptors; skin; somesthetic sensory cortex; stimulus /response; NMDA receptors; Saimiri; autoradiography; brain electrical activity; brain imaging /visualization /scanning; brain metabolism; cats; evoked potentials; infrared microscopy; sensory receptors; skin; somesthetic sensory cortex; stimulus /response

The proposed experiments focus on studies of patterns of stimulus evoked activity in somatosensory cortex (SI), and in particular, on the activation patterns evoked by repetitive skin stimulation. In the 01 year, animal experiments using the C14-2DG metabolic mapping method (2DG) and the infrared optical recording method for imaging intrinsic cortical signals (IR imaging) will be performed. The goal is to obtain and compare IR and 2DG images of the cortical response to the same stimulus conditions. In years 02-05, the IR optical recording technique will be employed to characterize the effects on stimulus evoked SI activity patterns of (i) NMDA receptor block, (ii) different frequencies of vibrotactile stimulation, and (iii) differing spatiotemporal patterns of skin stimulation. It is anticipated that the proposed studies will provide novel and useful information about the consequences of stimulus- evoked interactions among the multiple and spatially distributed neuronal populations activated by cutaneous stimuli. The information to be obtained should fill major gaps in what is currently known about the somatosensory cortical response to skin stimulation-gaps attributable principally to inadequacies of the methodologies which, at least to date, have been emphasized by experiments. In addition, the findings should provide direction to ongoing modeling and simulation studies of stimulus- directed somatosensory cortical network dynamics and the underlying neural mechanisms.

提出的实验重点是唤起刺激模式的研究 体感皮质（SI）的活性，尤其是在 重复的皮肤刺激引起的激活模式。 在01中 一年，使用C14-2DG代谢映射法（2DG）进行动物实验 以及用于成像内在皮质的红外光学记录方法 将执行信号（IR成像）。 目标是获得和 比较皮质反应与相同刺激的IR和2DG图像 状况。 在02-05年，IR光学记录技术将是 用于表征对刺激诱发的Si活性的影响 （i）NMDA受体块的模式，（ii）不同的频率 纤维状刺激和（iii）不同的时空模式 皮肤刺激。 预计拟议的研究将 提供有关刺激后果的新颖有用的信息 多个和空间分布的神经元之间的诱发相互作用 皮肤刺激激活的种群。 信息是 获得的应填补有关目前已知的主要空白 归因于皮肤刺激差距的体感皮质反应 主要是不足的方法论，至少到目前为止 已经通过实验强调。 此外，发现应该 为刺激的持续建模和模拟研究提供了方向 定向体感皮质网络动力学和基础 神经机制。