Rhythms of the Nervous System

神经系统的节律

• 批准号: 6941594
• 负责人: NANCY KOPELL
• 金额: $ 32.71万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941594
• 关键词: action potentials; attention; brain electrical activity; cognition; gap junctions; hippocampus; laboratory rat; mathematical model; memory; neocortex; nervous system; neural plasticity; neuroanatomy; neurophysiology; perception; sensory mechanism; sensory signal detection

DESCRIPTION (provided by applicant): Rhythms of the nervous system have been linked to important behavioral and cognitive states, including attention, working memory, associative memory, bottom-up feature binding, object recognition, sensory motor integration, perception and language processing. Pathologies in the rhythms have been linked to schizophrenia and Alzheimer's disease. Although these rhythms have been detected both in vitro and in vivo, how they participate in cognition is still not understood. The general aim of this proposal is to make use of biophysical information about cells and synapses in modeling studies to understand the origin and mechanisms of coherence of the various rhythms displayed in nervous system. Some of this information exists from previous experiments. Other data will be gathered in experiments proposed here. The proposal focuses on three important rhythms: gamma (30-80 Hz), beta (12-30 Hz) and theta (4-11 Hz). A major goal of this work is to understand how the mechanisms that produce the rhythms influence the way the nervous system processes structured input. There are many experimental paradigms that produce different versions of rhythms with the same frequency range. These are analogues of different in vivo situations, and can have different reactions to pharmacological perturbations. In different versions of the same frequency rhythm, there are different synaptic conductances that are critical and there may be different classes of interneurons participating. The modeling aims to probe the roles of the different intrinsic and synaptic currents in producing the individual rhythms and the interactions among them, including nesting rhythms and the transitions among them that are associated with changes of behavioral state. Experiments, done in tandem, aim to reveal more details of the electrophysiological and pharmacological properties of the classes of interneurons, and roles of electrical synapses in producing rhythms. There will also be experiments aimed at teasing out different rhythms in different layers of the neocortex. Other experimental paradigms will probe effects of sensory stimuli, the importance of synaptic plasticity in the transformation among rhythms, and the conditions under which nesting of gamma and theta occur. We will also study, both experimentally and via modeling, separated networks that produce a coherent gamma rhythm, and networks distributed over space.

描述（由申请人提供）：神经系统的节奏与重要的行为和认知状态有关，包括注意力，工作记忆，关联记忆，自下而上的特征绑定，对象识别，感觉运动集成，感知和语言处理。节奏中的病理与精神分裂症和阿尔茨海默氏病有关。尽管这些节奏在体外和体内都被检测到，但它们如何参与认知仍然尚不清楚。该提案的一般目的是利用有关细胞和突触的生物物理信息在建模研究中，以了解神经系统中显示的各种节奏相干性的起源和机制。这些信息中的一些来自以前的实验。其他数据将在此处提出的实验中收集。该提案重点介绍了三种重要的节奏：伽玛（30-80 Hz），beta（12-30 Hz）和theta（4-11 Hz）。这项工作的主要目标是了解产生节奏的机制如何影响神经系统处理结构化输入的方式。有许多实验范式产生具有相同频率范围的不同版本的节奏。这些是不同体内情况的类似物，并且可能对药理扰动产生不同的反应。在相同频率节奏的不同版本中，存在不同的突触电导，可能会有不同类别的中间神经元参与。该建模旨在探讨不同内在和突触电流在产生单个节奏以及它们之间的相互作用中的作用，包括嵌套节奏以及与行为状态变化相关的过渡。实验串联完成，旨在揭示中间神经元类的电生理学和药理特性的更多细节，以及电突触在产生节奏中的作用。还将进行旨在在新皮层不同层中取消不同节奏的实验。其他实验范式将探测感觉刺激的影响，突触可塑性在节奏转化中的重要性以及伽马和theta嵌套的条件。我们还将在实验和建模上研究产生连贯的伽马节奏的分离网络，以及分布在空间上的网络。

项目成果

Mechanism and circuitry for clustering and fine discrimination of odors in insects.

昆虫气味聚类和精细辨别的机制和电路。

• DOI: 10.1073/pnas.0407858101
• 发表时间: 2004
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Sivan,Ehud;Kopell,Nancy
• 通讯作者: Kopell,Nancy

IRIS: intermolecular RNA interaction search.

• DOI: 10.11234/gi1990.15.2_92
• 发表时间: 2004
• 期刊: Genome informatics. International Conference on Genome Informatics
• 作者: D. Pervouchine

Oscillations and slow patterning in the antennal lobe.

触角叶中的振荡和缓慢模式。

• DOI: 10.1007/s10827-006-4087-z
• 发表时间: 2006
• 期刊: Journal of computational neuroscience
• 影响因子: 1.2
• 作者: Sivan,Ehud;Kopell,Nancy
• 通讯作者: Kopell,Nancy

Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus.

编码内嗅皮层和海马体动态的低维图。

• DOI: 10.1162/neco.2006.18.11.2617
• 发表时间: 2006
• 期刊: Neural computation
• 影响因子: 2.9
• 作者: Pervouchine,DmitriD;Netoff,TheodenI;Rotstein,HoracioG;White,JohnA;Cunningham,MarkO;Whittington,MilesA;Kopell,NancyJ
• 通讯作者: Kopell,NancyJ