Towards the Development of an Efficient One-Carbon Homologation Strategy for Alkenes

开发高效的烯烃一碳同系化策略

• 批准号: 2468368
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2468368
• 关键词: Towards; Development; Efficient; Carbon; Homologation

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: The project looks at the long-term goal of developing a general, one-pot, one-carbon carbon homologation strategy for alkenes. The proposed transformation consists of two individual reactions that could potentially work in one-pot, or one-step, cross-metathesis of the substrate olefin with allyl hydrazine, followed by a tandem in situ elimination-reductive 1,3-transposition of the hydrazine to yield the homologated olefin.We will first investigate the suitability of tosyl and nosyl hydrazine substrates for the allylic diazene rearrangement. Secondly, the compatibility of the tosyl and nosyl hydrazine substrates will be explored in cross-metathesis with a simple terminal alkene, 4-phenyl-butene.

第一年：针对 CDT 所有一年级学生成员的通用培训​​活动。第二年至第四年：该项目着眼于制定烯烃的通用、一锅、一碳碳同系化策略的长期目标。所提出的转化由两个单独的反应组成，这些反应可能以一锅或一步的方式进行，底物烯烃与烯丙基肼的交叉复分解，然后是肼的串联原位消除-还原1,3-转座我们将首先研究甲苯磺酰基和对硝基肼底物对烯丙基二氮烯重排的适用性。其次，将探讨甲苯磺酰基和对硝基苯磺酰肼底物与简单末端烯烃 4-苯基丁烯的交叉复分解反应的相容性。