UAB/BVAMC Clinical Center in COPD

UAB/BVAMC 慢性阻塞性肺病临床中心

• 批准号: 6951233
• 负责人: WILLIAM C BAILEY
• 金额: $ 47.98万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951233
• 关键词: Streptococcus pneumoniae vaccine; biomarker; bronchodilators; chronic obstructive pulmonary disease; clinical research; clinical trials; comorbidity; cooperative study; corticosteroids; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; immune tolerance /unresponsiveness; inflammation; inhalation drug administration; patient oriented research; prednisolone; respiratory disease /disorder therapy; respiratory disorder chemotherapy; respiratory pharmacology; training

DESCRIPTION (provided by applicant): Chronic Obstructive Pulmonary Disease (COPD) is a serious public health problem responsible for more than 500, 000 hospitalizations, 100,000 deaths, and $15 billion in direct costs of medical care in the United States each year. We propose to form a collaborative COPD CRN Clinical Center at the University of Alabama at Birmingham (UAB) and the Birmingham Veterans Affairs Medical Center (BVAMC). The UAB/BVAMC Clinical Center will be headed by, Drs. William C. Bailey and J. Allen D. Cooper. The proposed investigators and their research staff have extensive experience in recruitment and retention for clinical trials, as well as study design and implementation. The collaborative effort between UAB and the BVAMC will allow us to quickly and efficiently recruit large numbers of COPD patients for clinical research studies. In addition, the UAB/BVAMC COPD Clinical Center will have access to a large network of experts at the University of Alabama at Birmingham who can assist in the design and implementation of clinical trials. The UAB/BVAMC Clinical Center proposes two studies aimed at enhancing treatment for moderate-to severe COPD. The first study will examine measures of inflammation and responsiveness to bronchodilator challenge, responsiveness to systemic steroid treatment, and responsiveness to inhaled steroid treatment. This study may provide a new method for identifying subgroups of COPD patients who are most likely to respond to inhaled corticosteroids. The second project will examine the causes of poor responsiveness to the pneumococcal vaccine with the long term goal of using this information to reduce pneumococcal infections and related exacerbations in COPD patients. The UAB/BVAMC Clinical Center also proposes a Clinical Research Skills Training Core. Dr. J. Allen D. Cooper, the Director for fellowship training in Pulmonary and Critical Care Medicine at UAB, will head this core. Trainees will be funded for a total of two years and will be required to enroll in one of the UAB K30 Clinical Research Curriculum Development Award components (either the Clinical Research Training Program or the Master's of Science in Public Health in Clinical Research). Trainees will also receive funding for a pilot project, which will be developed and conducted under the supervision of the Training Core Investigators. These Investigators have expertise in COPD, Clinical Research and Study Design, Behavioral Science, Epidemiology, and Statistics.

描述（由申请人提供）： 慢性阻塞性肺部疾病（COPD）是一个严重的公共卫生问题，每年在美国造成500多个住院，100,000人死亡和150亿美元的直接医疗费用。 我们建议在阿拉巴马大学伯明翰（UAB）和伯明翰退伍军人事务医疗中心（BVAMC）建立一个合作的COPD CRN临床中心。 UAB/BVAMC临床中心将由博士领导。 William C. Bailey和J. Allen D. Cooper。 拟议的研究人员及其研究人员在临床试验以及研究设计和实施方面具有丰富的招聘和保留经验。 UAB与BVAMC之间的协作工作将使我们能够快速有效地招募大量COPD患者进行临床研究。 此外，UAB/BVAMC COPD临床中心将可以在伯明翰阿拉巴马大学的大型专家网络中获得庞大的专家网络，该网络可以协助设计和实施临床试验。 UAB/BVAMC临床中心提出了两项​​研究，旨在增强中度至重度COPD的治疗方法。第一项研究将检查炎症和对支气管扩张剂挑战的反应性，对全身类固醇治疗的反应以及对吸入类固醇治疗的反应性。 这项研究可能会提供一种新方法来识别最有可能对吸入皮质类固醇反应的COPD患者的亚组。第二个项目将检查对肺炎球菌疫苗反应不佳的原因，其长期目标是使用此信息来减少COPD患者的肺炎球菌感染和相关加重。 UAB/BVAMC临床中心还提出了临床研究技能培训核心。 UAB肺和重症监护医学奖学金培训主任J. Allen D. Cooper博士将领导这一核心。学员将总共资助两年，并将被要求参加UAB K30临床研究课程开发奖组成部分（临床研究培训计划或临床研究公共卫生硕士学位）。学员还将获得一个试点项目的资金，该项目将在培训核心调查人员的监督下开发和进行。这些研究者在COPD，临床研究和研究设计，行为科学，流行病学和统计学方面具有专业知识。