Auditory training and neural plasticity in older adults

老年人的听觉训练和神经可塑性

• 批准号: 6960572
• 负责人: Kelly Tremblay
• 金额: $ 21.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6960572
• 关键词: adult human (21+); age difference; aging; auditory stimulus; behavior test; behavioral /social science research tag; brain imaging /visualization /scanning; brain mapping; clinical research; cues; hearing; hearing disorders; human old age (65+); human subject; learning; magnetoencephalography; neural information processing; neural plasticity; sound perception

DESCRIPTION (provided by applicant): The long-term goals of the proposed research are to examine the effect of advancing age on auditory learning, and to identify the intracerebral sources underlying behaviorally measured gains in skills acquired with training. More specifically, using behavioral and physiological measures, we will characterize the effects of age on the acquisition, generalization, and retention of learned temporal cues. Motivation for this study stems from the fact that older adults, with and without hearing loss, have difficulty perceiving various types of time-varying acoustic cues. Moreover, there is increasing evidence that impaired perception results, in part, from age-related factors affecting neural synchrony. Over the past decade we, and others, have shown that auditory training can alter synchronous neural patterns and improve the perception of the trained temporal cue. However, much of what we know about auditory training and auditory plasticity is limited to young adults and animals. Because the largest proportion of the population with communication disorders is elderly, it is important to determine if older adults can benefit from auditory training, or, if age limits the capacity for neural and perceptual change.

描述（由申请人提供）：拟议研究的长期目标是检查年龄增长对听觉学习的影响，并确定通过训练获得的行为测量技能增益的大脑内来源。更具体地说，使用行为和生理测量，我们将描述年龄对习得时间线索的获取、概括和保留的影响。这项研究的动机源于这样一个事实：老年人，无论有没有听力损失，都很难感知各种类型的随时间变化的声音线索。此外，越来越多的证据表明，感知能力受损部分是由影响神经同步的年龄相关因素造成的。在过去的十年中，我们和其他人已经证明听觉训练可以改变同步神经模式并改善对受训练的时间线索的感知。然而，我们对听觉训练和听觉可塑性的了解大多仅限于年轻人和动物。由于患有沟通障碍的人口中最大比例是老年人，因此确定老年人是否可以从听觉训练中受益，或者年龄是否限制了神经和知觉变化的能力非常重要。