THE NEUROBIOLOGY OF ATTENTION IN FETAL ALCOHOL SYNDROME

胎儿酒精综合症注意力的神经生物学

• 批准号: 6917902
• 负责人: PAULA J LOCKHART
• 金额: $ 18.07万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6917902
• 关键词: attention; brain mapping; fetal alcohol syndrome; human subject; magnetic resonance imaging; neural information processing; neurobiology; patient oriented research

This is a request for a NIAAA Mentored Patient Oriented Research Career Development Award (K23). This proposal describes a 5-year plan for the development of the candidate into an independent researcher in clinical child psychiatry and will include an investigation of attention problems in Fetal Alcohol Syndrome (FAS). This project will employ neurobehavioral paradigms and volumetric magnetic resonance imaging to evaluate the hypothesis that abnormalities of attention observed in individuals with FAS are due to disturbances in both an "anterior" frontostriatal network hypothesized to contribute to difficulties in motor impersistence and response inhibition, and a "posterior " parietal network, hypothesized to contribute to difficulties with orientation shifting attention. Through the mentorship of experts in the fields of developmental behavioral neurology, child psychiatry and neuropsychology, the candidate will embark on a course of study and mentored research that will characterize cortical networks of attention in FAS. The results of this study will lay the foundation for the future investigation of possible neurobiologic and neurobehavioral biomarkers of attention network impairment in this population of prenatally exposed individuals. Short term career goals are to become familiar with neurobehavioral paradigms used in the assessment of attention; to become proficient in the understanding and use of volumetric magnetic imaging; and to understand the basics of research design, ethics, epidemiology, and biostatistics as it applies to clinical child psychiatry. Additionally, the protected time will allow a more in depth evaluation of the FAS behavioral phenotype, with additional study in neuropharmacology, neurophysiology, neuroanatomy and psychopathology as it applies to brain-behavior relationships arising from teratogenic exposure. Long term career goals are to use the skills obtained in the didactic courses, tutorials and the mentored research project to perform independent clinical child psychiatry research in the pathogenesis of neuropsychiatric disorders associated with prenatal alcohol exposure will be investigated further in future projects, with the goal of helping design more focused mental health treatment and psychosocial remedies for the environmental disability present in many of these individuals.

这是NIAAA指导的以患者为导向的研究职业发展奖（K23）的要求。该提案描述了一项为期5年的候选人发展为临床儿童精神病学独立研究人员的计划，并将包括对胎儿酒精综合征（FAS）的注意问题的研究。该项目将采用神经行为范式和体积磁共振成像，以评估以下假说：在FAS患者中观察到的注意力异常是由于“前层面”网络的干扰是造成的，这两个“前”额叶网络被认为有助于造成汽车的困难和“ posteriatientiation” Paresteriatienting porthersielfients Oriperiatienting parteries of parity pareielies pareieliel's parielielielie parielieSiel's parieSiel'转移注意力。通过在发育行为神经病学领域，儿童精神病学和神经心理学领域的专家指导，候选人将着手进行研究和指导的研究，以表征FAS中的皮质关注网络。这项研究的结果将为未来研究这种产前暴露的个体人群中可能的神经生物学和神经行为生物标志物奠定基础。短期职业目标是熟悉评估注意力的神经行为范式；精通体积磁成像的理解和使用；并了解适用于临床儿童精神病学的研究设计，伦理学，流行病学和生物统计学的基础。此外，受保护的时间将允许对FAS行为表型进行更深入的评估，并在神经药理学，神经生理学，神经解剖学和心理病理学上进行了其他研究，因为它适用于脑业余关系，这是由致病性暴露引起的。长期的职业目标是利用在教程，教程和指导研究项目中获得的技能，以在神经精神疾病的发病机理中进行独立的临床儿童精神病研究，并将在未来的项目中进一步研究与产前酒精暴露的神经精神疾病，并在未来的项目中进一步研究，以帮助设计更多地专注于精神健康治疗和心理社会的环境障碍。