THE NEUROBIOLOGY OF ATTENTION IN FETAL ALCOHOL SYNDROME - A PILOT STUDY

胎儿酒精综合症注意力的神经生物学 - 一项试点研究

• 批准号: 7604708
• 负责人: PAULA J LOCKHART
• 金额: $ 0.01万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604708
• 关键词: Anterior; Area; Attention; Attention deficit hyperactivity disorder; Behavioral; Child; Cognitive; Communities; Computer Retrieval of Information on Scientific Projects Database; Condition; Development; Ethanol; Fetal Alcohol Syndrome; Foundations; Funding; Grant; High Prevalence; Individual; Institution; Intelligence; Link; Literature; Neuraxis; Neurobiology; Neurological observations; Pilot Projects; Population; Purpose; Research; Research Personnel; Resources; Source; Structure; Toxic effect; United States National Institutes of Health; cost; disability; executive function; interest; neurobehavioral; neurobiological mechanism; neuropsychological; size; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this proposal is to obtain funding from the Neurobehavioral Research Unit (NBRU) to carry out the pilot study entitled "The Neurobiology of Attention in Fetal Alcohol Syndrome." The funds requested will cover the cost of performing and analyzing 80 MRIs (40 children with FAS and 40 matched controls), the materials and administration of neuropsychological assessments in the areas of attention, intelligence and executive functioning. The recruitment is estimated to take eighteen months with the analyses taking six months. This project is estimated to take two years to complete. Fetal Alcohol Syndrome (FAS) is one of the most common causes of preventable long-term cognitive and behavioral disability. These disabilities are hypothesized to be due in part to the direct and indirect toxic effects of ethanol on the developing central nervous system (CNS). This is a pilot study examining the neurobiology of attention in individuals with FAS-a condition that is linked to significant educational, social, and behavioral disability. Although attention problems in FAS have generated great interest in the research community, and are described in numerous articles, there are few scientific studies that have examined the underlying neurobiological mechanisms of attention in this population. This project will examine hypotheses that suggest that structures making up anterior and posterior networks of attention are developmentally damaged in children with FAS. The theoretical foundation of this argument is drawn from the vast neurobiological literature on Attention Deficit Hyperactivity Disorder, which appears to overlap significantly with preliminary neuroanatomical findings in individuals with FAS. Specifically, structures in the CNS that are found reduced in size in children with ADHD are also significantly reduced in children with FAS. As yet there is little mention in the literature associating developmental alteration of these cortical and sub-cortical areas in FAS and the high prevalence of attention problems in these individuals.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案的目的是从神经行为研究部（NBRU）获得资金，以进行题为“胎儿酒精综合征注意的神经生物学”的试点研究。所要求的资金将涵盖进行和分析80个MRI的成本（40名具有FAS和40个匹配对照的儿童），在关注，智能和执行功能领域的神经心理学评估的材料和管理。招募估计需要18个月的时间，分析需要六个月。据估计，该项目需要两年才能完成。 胎儿酒精综合征（FAS）是可预防长期认知和行为障碍的最常见原因之一。假设这些残疾部分是由于乙醇对发展中心神经系统（CNS）的直接和间接毒性作用的部分原因。这是一项试点研究，研究了与大量教育，社会和行为障碍有关的FAS-A疾病患者的神经生物学。尽管FAS中的注意力问题对研究界产生了极大的兴趣，并且在许多文章中被描述了，但很少有科学研究检查了该人群中关注的潜在神经生物学机制。 该项目将研究假设，这些假设表明，在FAS儿童中，构成前后和后部注意力的结构在发育中受到了损害。这一论点的理论基础是从注意力缺陷多动障碍的广泛神经生物学文献中得出的，这似乎与FAS个体的初步神经解剖学发现显着重叠。具体而言，在患有ADHD儿童的儿童中，中枢神经系统的结构在患有ADHD的儿童中也大大降低。到目前为止，在FAS中这些皮质和亚皮质区域的发育改变以及这些人的注意力问题的高度流行率的文献中几乎没有提及。