CORE--CLINICAL

核心--临床

• 批准号: 6564822
• 负责人: WILLIAM R AUGER
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564822
• 关键词: adult respiratory distress syndrome; biomedical facility; data management; diagnostic respiratory lavage; human tissue; lung injury; patient /disease registry; pulmonary surfactants; sample collection

(Adapted from the Applicant's Abstract) The Clinical Core of this Acute Lung Injury SCOR is designed as a key support unit to promote the overall scientific objectives of the SCOR effort. This Core will be responsible for obtained and recording all clinical-physiologic-laboratory data relating to other samples from patients needed by SCOR investigators; and for the appropriate handling, storage/transport of such samples. In addition, the Clinical Core will collaborate with the Clinical Cores within other SCORs to standardize the collection and management of patient data and analysis of such pooled data. Of particular interest to other Acute Lung Injury SCORs may be access to samples from the UCSD patient population of individuals undergoing pulmonary art6ery thromboendarterectomy (PT-E). Of these patients, approximately two thirds develop acute lung injury. Because of the predictable nature of the injury, it is possible to collect serial samples of plasma and lavage fluid prior to injury, during the acute phase of injury, and during resolution. Such samples may be of interest of investigators in other SCORs, and, together with correlative physiologic and clinical data are available through the UCSD Clinical Core. Therefore, specific aims of this Clinical Core reflect these overall objectives; namely, 91) collection, organization and entry of clinical- physiologic-laboratory data from all patients studied within the SCOR in a specially-designed computer-software system which facilitates retrieval and analysis; (2) coordination with all SCOR investigators in the acquisition and appropriate handling of tissue and other samples required by SCOR investigators; (3) identification of patients with, or at risk, or ARDS and such with other SCOR Clinical Cores in an effort to standardize the collection and management of patients data and analyze such pooled data.

（改编自申请人的摘要）该急性肺损伤 SCOR 的临床核心被设计为促进 SCOR 工作总体科学目标的关键支持单位。该核心将负责获取并记录与 SCOR 研究人员所需的患者其他样本相关的所有临床生理实验室数据；以及此类样品的适当处理、储存/运输。此外，临床核心将与其他 SCOR 内的临床核心合作，以标准化患者数据的收集和管理以及此类汇总数据的分析。对其他急性肺损伤 SCOR 特别感兴趣的可能是获取来自接受肺动脉血栓内膜切除术 (PT-E) 的 UCSD 患者群体的样本。在这些患者中，大约三分之二出现急性肺损伤。由于损伤的可预测性，可以在损伤前、损伤急性期和恢复过程中收集血浆和灌洗液的连续样本。此类样本可能会引起其他 SCOR 的研究人员的兴趣，并且可以通过 UCSD 临床核心获得相关的生理和临床数据。因此，本临床核心的具体目标反映了这些总体目标；即，91) 在专门设计的计算机软件系统中收集、组织和输入 SCOR 内研究的所有患者的临床生理实验室数据，该系统有利于检索和分析； (2) 与所有 SCOR 研究者协调，获取和适当处理 SCOR 研究者所需的组织和其他样本； (3) 使用其他 SCOR 临床核心识别患有 ARDS 或有风险的患者等，以标准化患者数据的收集和管理并分析此类汇总数据。