CLINICAL MODELS OF THE ADULT RESPIRATORY DISTRESS SYNDROME

成人呼吸窘迫综合征的临床模型

• 批准号: 6564818
• 负责人: WILLIAM R AUGER
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564818
• 关键词: adult respiratory distress syndrome; antioxidants; cell adhesion; clinical research; clinical trials; cytokine; diagnostic respiratory lavage; elastase inhibitor; endarterectomy; glutathione analog; human subject; human therapy evaluation; neutrophil; nitric oxide; postoperative complications; pulmonary circulation obstruction; pulmonary edema; reperfusion; respiratory disorder chemotherapy; respiratory therapy; selectins; thromboembolism

(Adapted from the Applicant's Abstract): This project of the UCSD/ACUTE Lung Injury SCOR focuses on the prevention or amelioration of acute lung injury using targeted interventions based on observations which define the specific mechanisms responsible for acute lung injury. The human model used for these projects consists of patients undergoing pulmonary thromboendarterectomy (PT-E). Up to 60 percent of these patients develop a high permeability edema/reperfusion lung injury following PT-E. The aims of this project are to continue to define this unique, predictable, model of lung injury in PT-E patients by collecting sequential blood and BALF samples from PT-E and other patients at risk for ARDS and analyzing these samples for markers of ALI [neutrophil and protein influx, cytokines (IL-8, TNF-alpha), oxidized alpha1-proteinase inhibitor, glutathione levels, and soluble adhesion molecules (E-P-, L-selectins, ICAM-1, VCAM-1)]. The three interventional trials proposed analog, (2) use of an anti-oxidant drug, and (3) inhaled nitric oxide in the prevention of reperfusion of reperfusion lung injury. In addition to assessing the efficacy and safety of these three interventions, serial blood and bronchoalveolar lavage specimens will be collected prior to, during the acute phase, and during resolution of acute lung injury. Analysis of these specimens will provide insights into the cellular components and mediators that are involved in the initiation and perpetuation of acute lung injury. These specimens will be shared with collaborators working on other SCOR projects at UCSD and, if desired, with other Acute Lung Injury SCORs. (End of Abstract)

（改编自申请人的摘要）：UCSD/ACUTE Lung Injury SCOR 的这个项目侧重于使用基于观察的有针对性的干预措施来预防或改善急性肺损伤，这些观察定义了导致急性肺损伤的具体机制。用于这些项目的人体模型由接受肺血栓内膜切除术（PT-E）的患者组成。高达 60% 的患者在 PT-E 后出现高渗透性水肿/再灌注肺损伤。该项目的目的是通过收集 PT-E 和其他有 ARDS 风险的患者的连续血液和 BALF 样本并分析这些样本的 ALI 标记物，继续定义 PT-E 患者的这种独特的、可预测的肺损伤模型[中性粒细胞和蛋白质流入、细胞因子（IL-8、TNF-α）、氧化 α1-蛋白酶抑制剂、谷胱甘肽水平和可溶性粘附分子（E-P-、L-选择素、 ICAM-1、VCAM-1)]。这三项介入试验提出了类似的方法，（2）使用抗氧化药物，（3）吸入一氧化氮来预防再灌注肺损伤。 除了评估这三种干预措施的有效性和安全性外，还将在急性肺损伤之前、急性期和消退期间收集连续血液和支气管肺泡灌洗样本。对这些样本的分析将有助于深入了解参与急性肺损伤的发生和持续的细胞成分和介质。这些标本将与加州大学圣地亚哥分校其他 SCOR 项目的合作者共享，如果需要，也可与其他急性肺损伤 SCOR 共享。 （摘要完）