ADHD Symptoms in Autism: Cognition, Behavior, Treatment

自闭症的多动症症状：认知、行为、治疗

• 批准号: 6929581
• 负责人: DEBORAH Ann PEARSON
• 金额: $ 29.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-12 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6929581
• 关键词: attention; attention deficit disorder; autism; behavioral /social science research tag; child psychology; clinical research; clinical trials; comorbidity; human subject; human therapy evaluation; impulsive behavior; mental disorder chemotherapy; methylphenidate; middle childhood (6-11); patient oriented research; psychological tests; psychopharmacology; questionnaires

DESCRIPTION (provided by applicant): The proposed project, submitted in response to PA-04-085 will study cognitive and behavioral functioning in children with DSM-IV Autistic Disorder who also manifest symptoms of Attention Deficit Hyperactivitv Disorder (ADHD). Although the DSM-IV does not specifically allow for a comorbid diagnosis of ADHD with Autism, many children with Autism manifest symptoms of ADHD, and many are treated for it. There have been few studies on ADHD in Autism, so little is known about its cognitive and behavioral manifestations, or the optimal parameters for treatment. The proposed project will address these issues by examining cognitive and behavioral functioning in children with Autism who manifest symptoms of ADHD, as well as their response to stimulant medication treatment. Building upon techniques developed in the PI's previous NIMH-funded studies (MH044118 and MH48212, DA Pearson, PI) as well as her collaborative work in a current NICHD autism program project (HD035471; KA Loveland, PI; DA Pearson, Co-lnv.), this proposed study will address two Specific Aims. In Specific Aim 1, cognitive and behavioral functioning as well as comorbid psychiatric symptomatology will be compared in: 1) children with Autism who manifest symptoms of ADHD ("Autism/ADHD"), and 2) children with Autism who do not manifest symptoms of ADHD ("Autism/non-ADHD"). In both groups, children will be 7-12 years old, with an IQ of 50-130. It is hypothesized that relative to children, children in the Autism/non-ADHD group, with Autism/ADHD will have greater deficits in attention and inhibition, as well as more internalizing and externalizing psychiatric symptomatology. In Specific Aim 2, the cognitive and behavioral response to placebo, low, medium, and high doses of methylphenidate (MPH) in children with Autism/ADHD will be studied in a medication treatment trial, using a double-blind, placebo-controlled, crossover design to determine optimal MPH dosages. It is hypothesized that higher MPH doses will produce successive improvements in cognitive and behavioral functioning in children with Autism/ADHD. Thus, the primary goals of the proposed research are to characterize ADHD in school-aged children with Autistic Disorder (DSM-IV), and to assess their cognitive and behavioral response to MPH.

描述（由申请人提供）：针对 PA-04-085 提交的拟议项目将研究患有 DSM-IV 自闭症障碍的儿童的认知和行为功能，这些儿童也表现出注意力缺陷多动障碍 (ADHD) 的症状。尽管 DSM-IV 并未明确允许 ADHD 与自闭症共存诊断，但许多自闭症儿童表现出 ADHD 症状，并且许多人正在接受治疗。关于自闭症多动症的研究很少，因此对其认知和行为表现或最佳治疗参数知之甚少。拟议的项目将通过检查表现出多动症症状的自闭症儿童的认知和行为功能以及他们对刺激性药物治疗的反应来解决这些问题。 基于 PI 之前 NIMH 资助的研究（MH044118 和 MH48212，DA Pearson，PI）中开发的技术以及她在当前 NICHD 自闭症项目（HD035471；KA Loveland，PI；DA Pearson，Co-lnv. ），这项拟议的研究将解决两个具体目标。在具体目标 1 中，将比较以下对象的认知和行为功能以及共病精神症状：1) 表现出 ADHD 症状的自闭症儿童（“自闭症/ADHD”），以及 2) 不表现出 ADHD 症状的自闭症儿童多动症（“自闭症/非多动症”）。两组儿童年龄均为 7 至 12 岁，智商为 50 至 130。据推测，相对于儿童，自闭症/非多动症组的儿童在注意力和抑制方面有更大的缺陷，以及更多的内化和外化精神症状。在具体目标 2 中，将在药物治疗试验中研究自闭症/多动症儿童对安慰剂、低、中和高剂量哌醋甲酯 (MPH) 的认知和行为反应，使用双盲、安慰剂对照、交叉设计以确定最佳 MPH 剂量。据推测，较高的 MPH 剂量将使自闭症/多动症儿童的认知和行为功能连续改善。因此，本研究的主要目标是描述学龄自闭症儿童 (DSM-IV) 的 ADHD 特征，并评估他们对 MPH 的认知和行为反应。