Dynamic fMRI to measure neuronal activity

动态功能磁共振成像测量神经元活动

• 批准号: 6935382
• 负责人: Paul K Maciejewski
• 金额: $ 14.75万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-18 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935382
• 关键词: bioimaging /biomedical imaging; biological models; brain electrical activity; brain metabolism; carbon; cerebrovascular imaging /visualization; functional magnetic resonance imaging; hemodynamics; laboratory rat; method development; model design /development; neurophysiology; nuclear magnetic resonance spectroscopy; oxygen consumption; oxygen transport; stable isotope

DESCRIPTION (provided by applicant): Funding is requested to advance the research career of the Candidate, Dr. Paul K. Maciejewski. The overall aim of the project is to establish the Candidate, whose prior formal training has been in mechanical engineering and statistics, as an independent investigator in the areas of neurophysiology and brain functional magnetic resonance imaging (fMRI). The research career development plan consists of education/training and research components. Education in neurophysiology will be obtained primarily through courses offered in the Graduate Program in Neurobiology in the Yale University School of Medicine. Training in magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and metabolic modeling will be obtained primarily through training provided by experienced researchers at the Yale University Magnetic Resonance Center for Research in Metabolism & Physiology. Education and training in the ethical use of animals in research will be obtained primarily through the Yale Animal Resources Center. The research plan has three Specific Aims. These are: 1) Developing a 13C MRS method for measuring dynamic changes in cerebral metabolic rate of oxygen consumption, 2) obtaining dynamic, multi-modal measurements of functional activation in a rat model, and 3) developing a neurovascular model of blood oxygenation level dependent (BOLD) signal and functional activation. The Aims of the research plan will be achieved through applications and extensions of MRS, metabolic modeling, fMRI, electrophysiological measurements, and dynamic modeling. The outcomes of this basic research are expected to be relevant to diagnostic evaluation in neurology and psychiatry.

描述（由申请人提供）：请求资助以推进候选人 Paul K. Maciejewski 博士的研究事业。该项目的总体目标是让候选人成为神经生理学和脑功能磁共振成像 (fMRI) 领域的独立研究者，该候选人之前接受过机械工程和统计学方面的正式培训。研究职业发展计划由教育/培训和研究部分组成。神经生理学教育将主要通过耶鲁大学医学院神经生物学研究生项目提供的课程获得。磁共振波谱 (MRS)、磁共振成像 (MRI) 和代谢建模方面的培训将主要通过耶鲁大学代谢与生理学磁共振研究中心经验丰富的研究人员提供的培训来获得。在研究中道德使用动物的教育和培训将主要通过耶鲁大学动物资源中心获得。该研究计划有三个具体目标。这些是：1) 开发一种 13C MRS 方法，用于测量耗氧量的脑代谢率的动态变化，2) 获得大鼠模型中功能激活的动态、多模式测量，以及 3) 开发血氧水平的神经血管模型依赖性（粗体）信号和功能激活。该研究计划的目标将通过MRS、代谢模型、功能磁共振成像、电生理测量和动态模型的应用和扩展来实现。这项基础研究的结果预计将与神经病学和精神病学的诊断评估相关。