Dynamic fMRI to measure neuronal activity

动态功能磁共振成像测量神经元活动

• 批准号: 6534759
• 负责人: Paul K Maciejewski
• 金额: $ 13.66万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-18 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6534759
• 关键词: bioimaging /biomedical imaging; biological models; brain electrical activity; brain metabolism; carbon; cerebrovascular imaging /visualization; functional magnetic resonance imaging; hemodynamics; laboratory rat; method development; model design /development; neurophysiology; nuclear magnetic resonance spectroscopy; oxygen consumption; oxygen transport; stable isotope

DESCRIPTION (provided by applicant): Funding is requested to advance the research career of the Candidate, Dr. Paul K. Maciejewski. The overall aim of the project is to establish the Candidate, whose prior formal training has been in mechanical engineering and statistics, as an independent investigator in the areas of neurophysiology and brain functional magnetic resonance imaging (fMRI). The research career development plan consists of education/training and research components. Education in neurophysiology will be obtained primarily through courses offered in the Graduate Program in Neurobiology in the Yale University School of Medicine. Training in magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and metabolic modeling will be obtained primarily through training provided by experienced researchers at the Yale University Magnetic Resonance Center for Research in Metabolism & Physiology. Education and training in the ethical use of animals in research will be obtained primarily through the Yale Animal Resources Center. The research plan has three Specific Aims. These are: 1) Developing a 13C MRS method for measuring dynamic changes in cerebral metabolic rate of oxygen consumption, 2) obtaining dynamic, multi-modal measurements of functional activation in a rat model, and 3) developing a neurovascular model of blood oxygenation level dependent (BOLD) signal and functional activation. The Aims of the research plan will be achieved through applications and extensions of MRS, metabolic modeling, fMRI, electrophysiological measurements, and dynamic modeling. The outcomes of this basic research are expected to be relevant to diagnostic evaluation in neurology and psychiatry.

描述（由申请人提供）：要求资金推进候选人Paul K. Maciejewski博士的研究生涯。该项目的总体目的是建立候选人，其先前的正式培训是在机械工程和统计中，是神经生理学和脑功能磁共振成像（fMRI）领域的独立研究者。研究职业发展计划包括教育/培训和研究组成部分。神经生理学的教育将主要通过耶鲁大学医学院神经生物学研究生课程提供的课程获得。磁共振光谱（MRS），磁共振成像（MRI）和代谢建模的培训将主要通过耶鲁大学代谢与生理学研究研究中心经验丰富的研究人员提供的培训。动物在研究中道德使用方面的教育和培训将主要通过耶鲁动物资源中心获得。研究计划具有三个具体目标。这些是：1）开发一种13C MRS方法，用于测量氧气消耗的脑代谢速率的动态变化，2）在大鼠模型中获得功能激活的动态，多模式测量，以及3）开发一种血氧水平依赖（BOLD）信号和功能激活的神经血管模型。研究计划的目的将通过MRS，代谢建模，fMRI，电生理测量和动态建模的应用和扩展来实现。这项基础研究的结果有望与神经病学和精神病学的诊断评估有关。