Laser Delivery System for Improved Thermal Therapy

用于改善热疗的激光传输系统

• 批准号: 6484312
• 负责人: Ashok Gowda
• 金额: $ 10万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-09 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6484312
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; dogs; fiber optics; laser therapy; metastasis; neoplasm /cancer thermotherapy; photocoagulation therapy; radiation dosage

DESCRIPTION (provided by applicant): The liver and brain are the most common sites of metastatic tumors. At the time of death, approximately two-thirds of patients with colorectal cancer have liver metastases. In addition approximately 83 percent of all brain cancers will be diagnosed as metastatic tumors. In this work, we propose to develop an improved laser thermal therapy system for treatment of cancer metastases. The BioTex Cooled Laser Delivery System will combine a novel cooled applicator and low power diode laser system. The proposed innovative applicator is designed to remove heat from both the fiber optic and tissue in contact with the applicator surface while maintaining a low profile and thereby causing less damage to normal tissue during placement. A reduction in temperature of the fiber optic applicator and surrounding tissue during laser irradiation will increase the overall light penetration into tissue, allow for longer exposure times, and produce larger photocoagulative lesions in a far safer manner than previously possible. Combining the novel applicator with a low-power diode laser that is reliable, convenient, and easy to use should greatly increase the overall appeal for laser therapy in the treatment of solid tumors. PROPOSED COMMERCIAL APPLICATION: This research is specifically targeted towards the development of a safer, more efficient minimally invasive treatment for metastatic tumors. Laser interstitial thermal therapy offers a unique opportunity for minimally invasive destruction of such tumors. A safer more efficient laser system would significantly increase the number of tumors amenable to laaser therapy and therefore result in a significant potential for commercial success.

描述（由申请人提供）：肝脏和大脑是最常见的 转移性肿瘤的部位。死亡时，大约三分之二 结直肠癌患者有肝转移。此外 大约 83% 的脑癌将被诊断为转移性 肿瘤。在这项工作中，我们建议开发一种改进的激光热疗法 治疗癌症转移的系统。 BioTex 冷却激光传输 系统将结合新型冷却涂抹器和低功率二极管激光系统。 所提出的创新涂抹器旨在消除热量 光纤和组织与涂抹器表面接触，同时保持 低调，从而在过程中对正常组织造成的损害较小 放置。降低光纤涂抹器的温度 激光照射时周围组织的整体光度会增加 渗透到组织中，允许更长的暴露时间，并产生更大的 以比以前更安全的方式治疗光凝病变。 将新颖的涂抹器与可靠的低功率二极管激光器相结合， 方便且易于使用应该会大大增加整体吸引力 激光疗法用于治疗实体瘤。 拟议的商业应用：这项研究专门针对开发一种更安全、更有效的转移性肿瘤微创治疗方法。 激光间质热疗法为微创破坏此类肿瘤提供了独特的机会。 更安全、更高效的激光系统将显着增加适合激光治疗的肿瘤数量，从而带来巨大的商业成功潜力。